Oral:

For benign gastric ulcers: Take 40 mg daily in the morning for 4 weeks. If not fully healed, continue for another 4 weeks.

For gastroesophageal reflux disease: Take 20-40 mg daily in the morning for 4 weeks. If not fully healed, continue for another 4 weeks. Maintenance dose: 20 mg daily, which may be increased to 40 mg daily.

For duodenal ulcers: Take 40 mg daily in the morning for 2 weeks. If not fully healed, continue for another 2 weeks.

For duodenal ulcers with Helicobacter pylori: Take 40 mg twice a day with Amoxycillin 1 g and Clarithromycin 500 mg, or Clarithromycin 250 mg and Metronidazole 400 mg, both twice daily for one week.

For prevention of NSAID-induced ulcers: Take 20 mg daily for those on long-term NSAID treatment.

For Zollinger-Ellison Syndrome: Start with 80 mg once daily, adjust based on response (elderly max 40 mg daily). Doses above 80 mg should be divided into two doses.

IV Injection:

For duodenal and gastric ulcers: 40 mg once daily for 7-10 days.

For gastroesophageal reflux disease with erosive esophagitis: 40 mg once daily for 7-10 days.

For preventing rebleeding in peptic ulcers: 80 mg IV, followed by 8 mg/hour infusion for 72 hours.

For acid aspiration prevention: 80 mg IV every 12 hours for 24 hours, followed by 40 mg every 12 hours.

For long-term management of Zollinger-Ellison Syndrome: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed.