Palnox
Form: Injection
Strength: 0.075mg/1.5ml
Generic Name: Palonosetron
Company: Drug International Ltd.
MRP:৳ 75.0 (Injection)
Is Antibiotic: No
Indications
Palnox is used to treat schizophrenia, including both the treatment of acute episodes and preventing future episodes. Palnox is also used to treat schizoaffective disorder either alone or with other medications such as antidepressants or mood stabilizers.
Pharmacology
Palnox is a psychotropic drug in the benzisoxazole class, and Palnox is the active form of Risperidone. Palnox works mainly by blocking dopamine receptors (D2) and serotonin receptors (5-HT2A). Palnox also affects alpha-adrenergic receptors (α1 and α2) and histamine (H1) receptors. However, Palnox does not interact with cholinergic muscarinic or adrenergic beta receptors.
Dosage & Administration
Schizophrenia:
Adults: Start with 6 mg/day. The recommended dose is between 3-12 mg/day, with a maximum of 12 mg/day.
Adolescents (Weight < 51 kg): Start with 3 mg/day. The recommended dose is 3-6 mg/day, with a maximum of 6 mg/day.
Adolescents (Weight ≥ 51 kg): Start with 3 mg/day. The recommended dose is 3-12 mg/day, with a maximum of 12 mg/day.
Schizoaffective Disorder: Adults: Start with 6 mg/day. The recommended dose is between 3-12 mg/day, with a maximum of 12 mg/day.
Interaction
Palnox is advised to be cautious when taking Palnox with other central nervous system (CNS) drugs or alcohol. Palnox may reduce the effectiveness of Levodopa and other dopamine agonists. Palnox can also cause low blood pressure when combined with other drugs that have the same effect.
If taken with strong CYP3A4/P-glycoprotein inducers (like carbamazepine), the dose of Palnox may need to be increased. On stopping the strong inducers, the dose of Palnox may need to be reduced.
Taking Palnox with divalproex sodium may increase its levels in the body by about 50%, so the dose may need adjustment.
Contraindications
There are no specific contraindications for this medication.
Side Effects
Common side effects of Palnox include fast heart rate, restlessness, drowsiness, shaking, muscle stiffness, anxiety, weight gain, upset stomach, constipation, and sore throat. In some cases, people may also experience allergic reactions.
Pregnancy & Lactation
Palnox is classified as Pregnancy Category C. There are no adequate studies in pregnant women, so Palnox should only be used if the benefits outweigh the risks. Palnox is found in human breast milk, so the benefits of breastfeeding should be considered against the unknown risks of infant exposure.
Precautions & Warnings
Palnox should be used with caution in patients with heart problems, long QT syndrome, or a history of neuroleptic malignant syndrome. Other conditions that require caution include tardive dyskinesia, high blood sugar, high cholesterol, obesity, high prolactin levels, low white blood cell count, seizures, and cognitive or motor impairment.
Overdose Effects
If an overdose occurs, there is no specific antidote for Palnox. General supportive care should be provided, and symptoms should be treated as they arise.
Therapeutic Class
Palnox is classified as an atypical neuroleptic drug.
Storage Conditions
Store Palnox in a cool, dry place, away from light. Keep Palnox out of the reach of children.
Similar Brands of Palonosetron (Injection – 0.075mg/1.5ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Palon IV/IM | Injection | 0.075mg/1.5ml | Pharmasia Ltd. | 75.0 |
| Paloron IV | Injection | 0.075mg/1.5ml | Ziska Pharmaceuticals Ltd. | 75.0 |
| Paloset | Injection | 0.075mg/1.5ml | Square Pharmaceuticals Ltd. | 75.22 |
| Palosis | Injection | 0.075mg/1.5ml | Eskayef Pharmaceuticals Ltd. | 75.0 |
| Palostar 0.075 | Injection | 0.075mg/1.5ml | Orion Pharma Ltd. | 75.0 |
| Palostat IV | Injection | 0.075mg/1.5ml | The Ibn Sina Pharmaceutical Ind. Ltd. | 75.0 |
| Palotic IV | Injection | 0.075mg/1.5ml | Popular Pharmaceuticals Ltd. | 75.0 |
| Paloxi 0.75 | Injection | 0.075mg/1.5ml | Beacon Pharmaceuticals Ltd. | 75.23 |
| Palzen | Injection | 0.075mg/1.5ml | Healthcare Pharmaceuticals Ltd. | 90.0 |
| Panoset 0.075 | Injection | 0.075mg/1.5ml | Opsonin Pharma Limited | 75.22 |
| Patron 1.5 | Injection | 0.075mg/1.5ml | The ACME Laboratories Ltd. | 75.0 |