Xamic 500
Form: Capsule
Strength: 500mg
Generic Name: Tranexamic Acid
Company: Renata Limited
MRP:৳ 22.0 (Strip=10)
Per Piece: ৳ 2.20
Is Antibiotic: No
Indications
Xamic 500 is used to prevent and treat bleeding in various situations such as lung and digestive bleeding, bleeding related to leukemia, cirrhosis, hemophilia, and other bleeding disorders. Xamic 500 is also used to stop bleeding during and after surgery, including heart, lung, and abdominal surgeries, and for shock after trauma. In urology, Xamic 500 helps prevent bleeding in prostate, bladder, and kidney surgeries. Xamic 500 can be used to treat bleeding after childbirth and certain conditions like excessive bleeding during menstruation. Xamic 500 is also useful in preventing bleeding during tonsil surgery and dental extractions. In cancer care, Xamic 500 helps reduce bleeding during surgeries and promotes the formation of a protective capsule around ovarian tumors.
Pharmacology
Xamic 500 is a medication made from tranexamic acid, which has a strong effect in stopping excessive bleeding. Xamic 500 works by blocking certain proteins that break down blood clots, making Xamic 500 10 times stronger than traditional blood-clotting medications. The medicine has a low toxicity, is absorbed quickly when taken by mouth, and works for a longer time than other similar medications. Xamic 500 doesn’t interfere with normal clotting and does not cause blood clotting problems even after long use.
Dosage & Administration
Adults: The usual dose is 500-1000 mg, taken 3 times a day. For prevention, the recommended dose is 0.5-1 gm orally, or 500 mg via injection. For treating bleeding, the oral dose is increased to 1-3 gm in divided doses. In urgent cases, the first dose is given via slow injection, followed by oral doses.
Children: For prevention, give 5-10 mg per kg of body weight daily in divided doses. For treatment, the dose is increased to 10-20 mg per kg. In some cases, the injection can be given slowly by vein, followed by oral doses. In small babies, the medicine can be mixed with water and given orally.
Elderly: No dosage reduction is needed unless there is kidney failure.
Interaction
Xamic 500 is not compatible with penicillin-containing solutions. Thrombolytic drugs like Streptokinase and Urokinase can reduce its effect. Using Xamic 500 along with estrogen-containing medications, like birth control pills, may increase the risk of blood clots. Xamic 500 should not be mixed directly with whole blood during transfusions.
Contraindications
Xamic 500 should not be used by individuals with known allergies to the medication or those with blood clotting disorders, including deep vein thrombosis, pulmonary embolism, or severe kidney problems.
Side Effects
Xamic 500 is usually well tolerated, but some may experience mild side effects like fatigue, eye irritation, nasal congestion, skin redness, or a rash. After taking Xamic 500 orally, some may feel nauseous, have diarrhea, or experience stomach discomfort. In rare cases, Xamic 500 may cause low blood pressure when standing up. If an allergic reaction occurs, treatment should be stopped and suitable therapy should be started.
Pregnancy & Lactation
Xamic 500 should not be taken during pregnancy, as its effects on the fetus are unknown. Xamic 500 passes into breast milk but in very small amounts, so Xamic 500 is unlikely to affect the baby.
Precautions & Warnings
Xamic 500 should be used with caution in patients who have excessive bleeding. For surgery, Xamic 500 should be started 24 hours before the operation and continued for 3-4 days afterward. For bleeding, treatment should continue for at least 24 hours after the bleeding stops. Xamic 500 should be avoided in severe kidney problems and used cautiously in milder forms. Extra care is needed for people with heart or liver problems.
Overdose Effects
Not applicable.
Therapeutic Class
Anti-fibrinolytic drugs, Haemostatic drugs.
Storage Conditions
Store in a dry place at 15-30°C, away from light, and out of reach of children.
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