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Moxacil

Form: Injection

Strength: 500mg/vial

Generic Name: Amoxicillin

Company: Square Pharmaceuticals Ltd.

MRP:৳ 32.88   (500mg vial)

Is Antibiotic: Yes

Indications

Moxacil is used to treat infections caused by bacteria that are sensitive to ß-lactamase negative strains. These infections include ear, nose, and throat infections like otitis media, sinusitis, tonsillitis, pharyngitis, and laryngitis. Moxacil also treats lower respiratory tract infections such as pneumonia, bronchitis, lung abscess, empyema, and bronchiectasis. Moxacil is used for skin and soft tissue infections like cellulitis, carbuncles, and infected wounds. Moxacil can treat genito-urinary tract infections such as pyelonephritis, cystitis, and urethritis, as well as venereal diseases like acute uncomplicated gonorrhoea. For dental abscess, Moxacil is used for short-term therapy. Additionally, Moxacil is used with Clarithromycin and Lansoprazole in triple therapy for treating H. pylori infection and duodenal ulcer disease, and to reduce the risk of duodenal ulcer recurrence.

Pharmacology

Moxacil is a broad-spectrum penicillin effective against a wide range of Gram-positive and Gram-negative bacteria. Moxacil works by inhibiting the production of the bacterial cell wall. Moxacil remains stable in stomach acid and is absorbed quickly after taking Moxacil orally. After taking an oral dose, peak blood levels are reached within 1 to 2 hours. Moxacil is well-distributed in various body tissues and fluids.

Dosage & Administration

Adults: 250 mg three times a day, increasing to 500 mg three times a day for more severe infections.

Children (up to 10 years old): 125 mg three times a day, increasing to 250 mg three times a day for severe infections. For severe or recurrent respiratory infections, 3 gm every 12 hours is recommended.

Otitis Media: For adults, 1 g three times a day; for children, 40 mg/kg body weight daily in 3 divided doses (max. 3 g daily).

Pneumonia: 500-1000 mg three times a day is recommended.

Dental Abscess: 3 gm, repeated after 10-12 hours.

Urinary Tract Infections: 3 gm, repeated after 10-12 hours.

Gonorrhoea: A single dose of 2-3 gm with 1 gm Probenecid is recommended (Probenecid is not for children under 2 years old).

In Renal Impairment: Dosage may need to be reduced.

Interaction

Taking Moxacil with Probenecid may increase and prolong blood levels. Moxacil can affect the gut bacteria and reduce the effectiveness of combined oral contraceptives that contain estrogen and progesterone.

Contraindications

Moxacil should not be used in patients who are allergic to penicillin.

Side Effects

Side effects are generally mild and temporary. These may include diarrhea, indigestion, or occasionally a rash. Rarely, pseudo-membranous colitis has been reported.

Pregnancy & Lactation

Moxacil is classified as pregnancy category B by the FDA. There are no adequate and well-controlled studies in pregnant women, so Moxacil should be used during pregnancy only if clearly needed. Moxacil is excreted in human milk, so caution is advised when used by lactating mothers.

Precautions & Warnings

Superinfections with fungal or bacterial pathogens may occur during therapy. If this happens, Moxacil should be discontinued, and the appropriate treatment should be started.

Overdose Effects

Not applicable.

Therapeutic Class

Broad spectrum penicillins.

Storage Conditions

Store in a dry place, away from light and heat. Keep out of the reach of children.

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