Omastin
Form: Powder for Suspension
Strength: 50mg/5ml
Generic Name: Fluconazole
Company: Beximco Pharmaceuticals Ltd.
MRP:৳ 78.0 (35ml bot)
Is Antibiotic: No
Indications
Omastin is used to treat various fungal infections, including vaginal, oral, and esophageal candidiasis, as well as infections of the skin (Tinea), nails (Onychomycosis), and hair (Kerion). Omastin is also used to treat cryptococcal infections (including meningitis) and prevent cryptococcal meningitis in patients at risk. Additionally, Omastin is used to prevent fungal infections in patients with weakened immune systems and for systemic fungal infections such as histoplasmosis and coccidioidomycosis.
Pharmacology
Omastin is a type of antifungal medication that works by blocking the production of ergosterol, an essential component of fungal cell membranes, by inhibiting fungal enzymes. This helps in treating fungal infections by weakening the cell structure of the fungus.
Dosage & Administration
Adults:
- Vaginal Candidiasis: 150 mg as a single dose.
- Oropharyngeal Candidiasis: 200 mg on the first day, then 100 mg daily for 14 days.
- Oesophageal Candidiasis: 200 mg on the first day, then 100 mg daily for 14-30 days.
- Tinea (skin infections): 150 mg weekly for 4-6 weeks.
- Kerion: 50 mg daily for 20 days.
- Pityriasis versicolor: 400 mg as a single dose.
- Onychomycosis (nail infections): 150 mg weekly for 12 months.
- Invasive candidal infections and cryptococcal infections: 400 mg on the first day, then 200-400 mg daily.
- Prevention of cryptococcal meningitis: 200 mg daily.
- Prevention of fungal infections in immunocompromised patients: 50-400 mg daily.
Children (over 1 year):
- For superficial candidiasis: 1-2 mg/kg daily.
- For systemic infections: 3-6 mg/kg daily.
- For serious infections in children aged 5-13 years, doses up to 12 mg/kg daily (maximum 400 mg daily) may be used.
For renal impairment: Dosage may need adjustment based on kidney function.
Interaction
Omastin can interact with certain medications. For example, Omastin can increase the effects of blood thinners like warfarin. Omastin may also affect the blood sugar levels when taken with diabetes medications. Other drugs that may interact include diuretics, phenytoin, and rifampicin. Patients should be monitored for any changes in their treatment when taking Omastin alongside other drugs.
Contraindications
Omastin should not be used by people who are allergic to Omastin or related medications in the same group.
Side Effects
Common side effects include stomach issues like nausea, abdominal discomfort, diarrhea, and gas. Other side effects like rash are less common. In rare cases, serious allergic reactions like anaphylaxis and liver damage have been reported.
Pregnancy & Lactation
Omastin should be avoided during pregnancy or breastfeeding, unless absolutely necessary, due to limited human data and potential risks to the baby.
Precautions & Warnings
Patients with severe liver or kidney disease should use caution. If liver problems develop, treatment should be stopped. If a rash appears, Omastin may indicate a serious reaction, and the medication should be discontinued. Monitoring is advised for those with serious underlying conditions, such as AIDS.
Overdose Effects
In case of overdose, immediate medical help should be sought. Treatment may include measures like gastric lavage and diuresis. Dialysis can help remove the drug from the body more quickly.
Therapeutic Class
Antifungal medication for treating fungal infections.
Storage Conditions
Store in a dry place, away from light and heat, and out of reach of children.
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