Tablet and Suspension:
Trichomoniasis (Adults & Children over 10 yrs):
200 mg three times a day or 400 mg twice a day for 7 days.
800 mg in the morning and 1-2 gm at night for 2 days.
2 gm once a day for 1 day.
Trichomoniasis (Children):
Children 7-10 yrs: 100 mg three times a day.
Children 3-7 yrs: 100 mg twice a day.
Children 1-3 yrs: 50 mg three times a day.
Intestinal Amoebiasis (Adults & Children over 10 yrs):
800 mg three times a day for 5 days.
Intestinal Amoebiasis (Children):
Children 7-10 yrs: 400 mg three times a day.
Children 3-7 yrs: 200 mg four times a day.
Children 1-3 yrs: 200 mg three times a day.
Extra-intestinal & Asymptomatic Amoebiasis (Adults & Children over 10 yrs):
400-800 mg three times a day for 5-10 days.
Extra-intestinal & Asymptomatic Amoebiasis (Children):
Children 7-10 yrs: 200-400 mg three times a day.
Children 3-7 yrs: 100-200 mg four times a day.
Children 1-3 yrs: 100-200 mg three times a day.
Giardiasis (Adults & Children over 10 yrs):
2 gm once a day for 3 days.
Giardiasis (Children):
Children 7-10 yrs: 1 gm once a day.
Children 3-7 yrs: 600-800 mg once a day.
Children 1-3 yrs: 500 mg once a day.
Acute Ulcerative Gingivitis (Adults & Children over 10 yrs):
200 mg three times a day for 3 days.
Acute Ulcerative Gingivitis (Children):
Children 7-10 yrs: 100 mg three times a day.
Children 3-7 yrs: 100 mg twice a day.
Children 1-3 yrs: 50 mg three times a day.
Acute Dental Infections (Adults & Children over 10 yrs):
200 mg three times a day for 3-7 days.
Bacterial Vaginosis (Adults & Children over 10 yrs):
400 mg twice a day for 7 days.
2 gm once a day for 1 day.
Leg Ulcers and Pressure Sores (Adults & Children over 10 yrs):
400 mg three times a day for 7 days.
Anaerobic Infections (Adults & Children over 10 yrs):
800 mg initially, then 400 mg three times a day for 7 days.
Anaerobic Infections (Children):
Children 1-10 yrs: 7.5 mg/kg three times a day.
Surgical Prophylaxis (Adults & Children over 10 yrs):
400 mg three times a day starting 24 hours before surgery for 1 day.
Surgical Prophylaxis (Children):
Children 1-10 yrs: 7.5 mg/kg three times a day.

Vaginal Gel:
One full applicator of gel (about 5 grams with 37.5 mg of the drug) is used once or twice a day for 5 days. Metro IV (OSL) is best to use Metro IV (OSL) at bedtime for once-a-day dosing.

Suppository:
Anaerobic Infections:
Adults: 1 gm every 8 hours for 3 days, then 1 gm every 12 hours.
Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years: adult dose.
Surgical Prophylaxis:
Adults: 1 gm 2 hours before surgery; up to 3 more doses of 1 gm every 8 hours for high-risk surgeries.
Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 more doses of 500 mg every 8 hours for high-risk surgeries.

IV Infusion:
No dilution is required for IV infusion, and Metro IV (OSL) should not be mixed with other drugs before giving. The dose for adults and children over 12 years is 500 mg every 8 hours at a rate of 5 ml/min, with a maximum of 4 gm per day. Most patients need 7 days of treatment, but Metro IV (OSL) can be extended. For surgical prophylaxis, Metro IV (OSL) is given before surgery and then continued every 8 hours for the next 24 hours.
For children under 12 years, the dose is 7.5 mg/kg body weight per day, divided into 3 doses every 8 hours at a rate of 5 ml/min.