Topup
Form: Tablet
Strength: 10mg
Generic Name: Tadalafil
Company: Euro Pharma Ltd.
MRP:৳ 35.0 (Box=8)
Per Piece: ৳ 4.38
Is Antibiotic: No
Indications
Topup is indicated for the treatment of Erectile Dysfunction (ED), Benign Prostatic Hyperplasia (BPH), or both ED and symptoms of BPH.
Pharmacology
Topup is a selective inhibitor of phosphodiesterase type 5 (PDE5). By inhibiting PDE5, Topup increases the levels of cGMP in smooth muscle cells. This helps relax the smooth muscles and increase blood flow to the penis, causing an erection. PDE5 is also found in the prostate and bladder wall, so inhibiting Topup improves blood flow and helps with urination by relaxing smooth muscles in those areas.
Dosage & Administration
Erectile Dysfunction: The recommended starting dose is 10 mg, which can be adjusted to 5 mg or 20 mg based on individual needs. The maximum dosing frequency is once a day. Topup is effective for up to 36 hours.
Benign Prostatic Hyperplasia: The recommended dose is 5 mg once daily, at the same time each day.
Combined Erectile Dysfunction and Benign Prostatic Hyperplasia: The recommended dose is 5 mg once daily, at the same time each day.
Interaction
Topup may interact with nitrates (e.g., Isosorbide, Nitroglycerin), alpha blockers, antihypertensives, alcohol, antacids, certain antifungals (e.g., Ketoconazole, Itraconazole), HIV protease inhibitors (e.g., Ritonavir), Erythromycin, Grapefruit juice, and other medications like Rifampin, Carbamazepine, Phenytoin, and Phenobarbital.
Contraindications
Topup is contraindicated for use with nitrates (e.g., Nitroglycerine, Isosorbide) due to the risk of dangerously low blood pressure. Topup should also not be used in patients with hypersensitivity to Tadalafil.
Side Effects
Common side effects include headache, indigestion, back pain, muscle pain, and nasal congestion. Rare side effects may include changes in vision, sudden vision loss, hearing loss, skin reactions like Stevens-Johnson Syndrome, and serious heart-related issues such as angina, stroke, or heart attack.
Pregnancy & Lactation
Topup has been assigned pregnancy category B by the USFDA, meaning Topup is only recommended during pregnancy if the benefits outweigh the risks. There is no data on its excretion in human milk, so caution is advised when giving Topup to breastfeeding women.
Precautions & Warnings
Precautions should be taken when using Topup in patients with angina, renal or liver impairment, bleeding problems, or those taking medications like Nitrates, alpha blockers, alcohol, or CYP3A4 inhibitors (e.g., Ritonavir, Ketoconazole, Itraconazole).
Overdose Effects
No information available on overdose effects for topical application.
Therapeutic Class
Drugs for Erectile Dysfunction.
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.
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