For Tablets & Syrup:

• Duodenal and gastric ulcers: 150 mg twice daily, or 300 mg once at night, for 4 to 8 weeks.
• Reflux esophagitis: 150 mg twice daily, or 300 mg at bedtime, for up to 8 weeks.
• Zollinger-Ellison syndrome: 150 mg three times daily, increased to up to 6 g daily in divided doses.
• Episodic dyspepsia: 150 mg twice daily, or 300 mg at bedtime, for up to 6 weeks.
• Maintenance: 150 mg at night to prevent recurrence.
• Children (peptic ulcer): 2-4 mg/kg twice daily, with a maximum of 300 mg daily.

For IV Injection & Infusion:

• 50 mg intravenous injection, diluted to 20 ml, every 6 to 8 hours or a 25 mg/hour infusion for two hours, repeated every 6 to 8 hours.
• For prevention of gastrointestinal bleeding in seriously ill patients, 50 mg intravenous injection followed by a continuous infusion of 0.125-0.250 mg/kg/hour.
• If at risk for aspiration syndrome, administer 50 mg intramuscularly or by slow intravenous injection 45 to 60 minutes before anesthesia.

Children: The recommended oral dose for treating peptic ulcer is 2 mg/kg to 4 mg/kg twice daily, up to a maximum of 300 mg per day. Safety of the IV injection in children has not been established.