Zedoxim
Form: Powder for Suspension
Strength: 20mg/ml
Generic Name: Cefpodoxime
Company: Globe Pharmaceuticals Ltd.
MRP:৳ 60.0 (15ml bot)
Is Antibiotic: Yes
Indications
Zedoxim is used for the treatment of the following infections:
- Acute bacterial flare-ups of chronic bronchitis
- Acute community-acquired pneumonia
- Pharyngitis or tonsillitis
- Skin and soft tissue infections
- Urinary tract infections
- Uncomplicated gonorrhea
- Acute maxillary sinusitis
Pharmacology
Zedoxim contains Cefpodoxime, a third-generation semi-synthetic Cephalosporin, which works against many Gram-positive and Gram-negative bacteria. Zedoxim is also resistant to beta-lactamase, an enzyme that would normally break Zedoxim down. Cefpodoxime is effective against various bacteria such as Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria species, and Moraxella catarrhalis.
Zedoxim also includes Clavulanic acid, which is a natural substance that inhibits beta-lactamase enzymes produced by certain bacteria. By stopping these enzymes, Clavulanic acid helps protect Cefpodoxime from being broken down and increases its effectiveness.
Dosage & Administration
For adults (12 years and older):
- Acute bacterial exacerbation of chronic bronchitis: 1 tablet every 12 hours for 10 days
- Acute community-acquired pneumonia: 1 tablet every 12 hours for 14 days
- Pharyngitis or tonsillitis: ½ tablet every 12 hours for 5 to 10 days
- Skin and soft tissue infections: 2 tablets every 12 hours for 7 to 14 days
- Urinary tract infections: ½ tablet every 12 hours for 7 days
- Uncomplicated gonorrhea: One single dose
- Acute maxillary sinusitis: 1 tablet every 12 hours for 10 days
For children: Children aged 2 months to 12 years: 10 mg/kg/day divided into two doses, every 12 hours.
Interaction
Taking high doses of Cefpodoxime together with antacids or H2 blockers may reduce the peak levels of Cefpodoxime in the blood.
Contraindications
Zedoxim is contraindicated for patients who are allergic to Cephalosporins.
Side Effects
Zedoxim is generally well tolerated. The most common side effects are gastrointestinal issues such as diarrhea, nausea, and stomach pain.
Pregnancy & Lactation
Zedoxim is classified as a pregnancy category B drug by the US FDA, meaning Zedoxim should only be used during pregnancy if absolutely necessary. There are no well-controlled studies in pregnant women. This drug is also present in breast milk, so caution is advised when administering Zedoxim to breastfeeding women.
Precautions & Warnings
Zedoxim should be used with caution in patients who are also taking diuretics.
Overdose Effects
No overdose effects have been reported.
Therapeutic Class
Zedoxim belongs to the third-generation Cephalosporin class of antibiotics.
Storage Conditions
Store in a dry place away from light and heat. Keep out of reach of children.