Cardivas 12.5
Form: Tablet
Strength: 12.5mg
Generic Name: Carvedilol
Company: Sun Pharmaceutical (Bangladesh) Ltd.
MRP:৳ 6.56 (Tablet)
Is Antibiotic: No
Indications
Cardivas 12.5 is used to treat mild, moderate, or severe heart failure caused by heart problems or heart muscle disease. Cardivas 12.5 works together with other medications like digitalis, diuretics, and ACE inhibitors to slow down disease progression, reduce cardiovascular death, prevent hospital visits, and avoid the need for changes in other heart failure treatments. Cardivas 12.5 can also be used in patients who cannot tolerate ACE inhibitors or in those not taking digitalis, hydralazine, or nitrates.
Pharmacology
Cardivas 12.5 is a heart-related drug that works by blocking β-adrenergic receptors and also has effects on a-adrenergic receptors. Additionally, Cardivas 12.5 helps prevent cell growth and removes harmful oxidant radicals from the body. Cardivas 12.5 is used to treat high blood pressure, chest pain (angina), and heart failure.
Dosage & Administration
For Hypertension: Start with 12.5 mg once a day. After 2 days, increase the dose to 25 mg once daily. If needed, the dose can be raised every 2 weeks to a maximum of 50 mg daily, either in one or two doses. Older patients may be fine with 12.5 mg daily.
For Angina: Start with 12.5 mg twice a day for the first 2 days. Then, increase to 25 mg twice daily. Older patients should not exceed 50 mg daily, divided into two doses.
For Heart Failure: Start with 3.125 mg twice a day (with food). Increase the dose every 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, and then to 25 mg twice daily. The highest dose depends on body weight: up to 25 mg twice daily for patients under 85 kg, and up to 50 mg twice daily for patients over 85 kg.
Interaction
Digoxin: Taking carvedilol with digoxin may increase digoxin levels in the body, so monitoring is recommended when starting or changing doses of carvedilol.
Rifampin: Taking rifampin before carvedilol can decrease the levels of carvedilol in the body by 60%.
Warfarin: Carvedilol does not change the way warfarin binds to proteins in the blood.
Clonidine: Stopping clonidine treatment suddenly while on carvedilol may cause high blood pressure, but carvedilol’s other effects may reduce this rise.
Contraindications
Cardivas 12.5 is not suitable for patients with severe heart failure needing inotropic therapy, asthma or related breathing problems, certain heart rhythm disorders, or those with severe slow heart rate or shock.
Side Effects
Possible side effects include low blood pressure when standing, dizziness, headache, tiredness, stomach issues, slow heart rate, poor circulation, swelling, dry mouth or eyes, eye irritation, impotence, trouble with urination, flu-like symptoms, rare cases of chest pain, heart block, worsening leg pain, allergic skin reactions, worsening psoriasis, stuffy nose, breathing difficulties, depression, sleep issues, tingling, heart failure, changes in liver enzymes, and low blood cell counts.
Pregnancy & Lactation
Cardivas 12.5 should not be used during breastfeeding as Cardivas 12.5 can pass into breast milk. Its safety in children is not known. Cardivas 12.5 is also not recommended during pregnancy as Cardivas 12.5 may pass through the placenta. Its safety in newborns is unknown.
Precautions & Warnings
Cardivas 12.5 should be used carefully in patients with liver problems and heart failure. Doctors should monitor the patient’s condition for a few hours after starting treatment or adjusting doses. Before increasing the dose, check that kidney function and heart failure are stable.
Overdose Effects
No information available.
Therapeutic Class
Alpha adrenoceptor blocking drugs, Beta-adrenoceptor blocking drugs, Beta-blockers.
Storage Conditions
Keep below 30°C, away from light and moisture. Keep out of reach of children.
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