A-One Plus
Form: tablet
Strength: 65mg+500mg
Generic Name: Paracetamol + Caffeine
Company: Square Pharmaceuticals Ltd.
MRP:৳ 2.4 (Strip=10)
Per Piece: ৳ 0.24
Is Antibiotic: No
Indications
A-One Plus is used for treating the following conditions:
- Headache
- Migraine
- Toothache
- Neuralgia
- Feverishness
- Period pain
- Sore throat
- Backache
- Helps reduce fever
- Aches and pains from colds and flu
Pharmacology
A-One Plus is a combination of Paracetamol and Caffeine. Paracetamol works to relieve pain and reduce fever, while Caffeine helps increase the effectiveness of Paracetamol by making A-One Plus easier to pass through the body. Caffeine also raises the pain tolerance and helps improve blood flow in the brain, which is useful for treating headaches and migraines.
Dosage & Administration
Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.
Child dose: Not recommended for children under 12 years.
Interaction
A-One Plus may interact with other medications like anticonvulsants (e.g., phenytoin, barbiturates, carbamazepine) by lowering serum levels. Prolonged use can increase the anticoagulant effect of warfarin. A-One Plus may also accelerate absorption with metoclopramide and domperidone, increase serum levels with probenecid and chloramphenicol, and reduce absorption when taken with colestyramine. Be cautious with phenothiazine as A-One Plus may cause severe hypothermia.
Contraindications
A-One Plus is contraindicated for patients with severe kidney or liver problems (e.g., Viral Hepatitis) and those who are allergic to Paracetamol or Caffeine.
Side Effects
Side effects are usually mild but may include blood issues such as thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis. Other rare side effects include pancreatitis, skin rashes, and allergic reactions.
Pregnancy & Lactation
If pregnant or breastfeeding, consult a doctor before using Paracetamol & Caffeine. A-One Plus is generally safe to use while breastfeeding.
Precautions & Warnings
Use cautiously in patients with liver or kidney issues or those on other liver-toxic medications. Prolonged use without a doctor’s consultation should be avoided.
Overdose Effects
Overdose symptoms within the first 24 hours may include pale skin, nausea, vomiting, loss of appetite, and stomach pain. Liver damage can appear 12-40 hours after ingestion. Other effects include abnormal blood sugar and metabolic acidosis.
Therapeutic Class
Non-opioid analgesics.
Storage Conditions
Store in a cool, dry place away from light and moisture. Keep out of reach of children.