Akicin 500
Form: Injection
Strength: 500mg/2ml
Generic Name: Amikacin
Company: Square Pharmaceuticals Ltd.
MRP:৳ 48.14 (Injection)
Is Antibiotic: Yes
Indications
Akicin 500 is used to treat serious infections caused by certain types of bacteria. Akicin 500 is effective in treating infections in the blood, lungs, bones, joints, nervous system (including meningitis), skin, and soft tissue. Akicin 500 also works for infections inside the abdomen, including peritonitis, as well as burns and infections after surgery. Akicin 500 has also been found to be effective for complicated or repeated urinary tract infections caused by resistant bacteria.
Akicin 500 is effective against infections caused by bacteria that are resistant to other antibiotics like gentamicin and tobramycin, especially against certain bacteria like Proteus rettgeri, Providencia stuartii, Serratia marcescens, and Pseudomonas aeruginosa.
Akicin 500 is also used to treat infections caused by staphylococci and can be used as a first treatment for severe infections, especially when the exact bacteria causing the infection are not known.
Pharmacology
Akicin 500 is a type of antibiotic known as an aminoglycoside. Akicin 500 is effective against a range of bacteria, including Pseudomonas, Escherichia coli, Proteus, and several other types. Many of these bacteria are resistant to other similar antibiotics, but they are still susceptible to Akicin 500. Akicin 500 is also effective against Staphylococcus species, including those resistant to methicillin.
Dosage & Administration
Adults and children: The typical dose is 15 mg per kilogram of body weight per day, split into two doses (which is 500 mg twice a day for adults).
Neonates and premature children: The initial dose is 10 mg per kilogram of body weight, followed by 15 mg per kilogram per day in two doses.
Elderly: Akicin 500 is cleared by the kidneys, so elderly patients should have their kidney function checked, and the dose may need to be adjusted.
Life-threatening infections or Pseudomonas infections: The dose may be increased to 500 mg every eight hours, but should not exceed 1.5 g per day, and should not be used for more than 10 days.
Urinary tract infections (except Pseudomonas): 7.5 mg per kilogram of body weight per day in two doses (250 mg twice a day for adults).
Impaired kidney function: The dose may need to be reduced or given less frequently in patients with kidney problems.
Interaction
Akicin 500 should not be used with muscle relaxants as Akicin 500 can increase their effects, potentially stopping breathing. Akicin 500 should not be combined with other aminoglycoside antibiotics because they can increase the risk of ear and kidney damage. Akicin 500 should also not be used with fast-acting diuretics if the patient has kidney problems, as Akicin 500 can increase the risk of ear damage. Combining Akicin 500 with Cephalosporins or Polymixins may also increase the risk of kidney damage.
Contraindications
Akicin 500 is not recommended for people who are allergic to Akicin 500 or any of its ingredients.
Side Effects
Some side effects may include ringing in the ears, dizziness, partial or complete hearing loss, skin rash, fever, headache, tingling, nausea, and vomiting.
Pregnancy & Lactation
Akicin 500 can cross the placenta and may harm the baby, potentially causing ear damage. There is no clear information about its safety while breastfeeding, so Akicin 500 should only be used if absolutely necessary and under medical supervision.
Precautions & Warnings
Since Akicin 500 is processed by the kidneys, Akicin 500 is important for patients to stay hydrated to avoid kidney damage. If kidney problems occur, the treatment should be stopped. Monitoring of kidney function is especially important during treatment with this antibiotic.
Overdose Effects
If an overdose occurs, dialysis (either peritoneal or hemodialysis) can help remove Akicin 500 from the blood.
Therapeutic Class
Aminoglycoside antibiotics
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Similar Brands of Amikacin (Injection – 500mg/2ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Amibac | Injection | 500mg/2ml | Popular Pharmaceuticals Ltd. | 48.18 |
| Amimax | Injection | 500mg/2ml | Biopharma Ltd. | 48.0 |
| Kacin 500 | Injection | 500mg/2ml | ACI Limited | 60.0 |
| Mikacin | Injection | 500mg/2ml | Aristopharma Limited | 45.0 |