Allphen
Form: Syrup
Strength: 5mg/5ml
Generic Name: Promethazine Hydrochloride
Company: Medimet Pharmaceuticals Ltd.
MRP:৳ 12.0 (50ml bot)
Is Antibiotic: No
Indications
Allphen is used as a strong and long-lasting antihistamine, with additional effects of reducing nausea and calming. Allphen is indicated for the treatment of allergic conditions affecting the respiratory system and skin. Allphen can also treat reactions to drugs or foreign proteins, including anaphylaxis. Allphen is used for sedation, managing allergic rhinitis, hives, and insomnia. Additionally, Allphen helps as a sedative before surgeries and in obstetrics. Allphen is also used as a pediatric sedative.
Pharmacology
Allphen is a type of medication that works by blocking certain receptors in the brain. Allphen also has a strong effect on certain blood vessels and reduces the release of specific hormones. Allphen competes with histamine to reduce allergic responses and may also block muscarinic receptors, which helps to prevent nausea. Allphen is absorbed well through the digestive system and starts to work within 20 minutes, lasting for 4-6 hours, although Allphen can last up to 12 hours. The body processes Allphen in the liver into various compounds, and these are then excreted through the urine.
Dosage & Administration
Adults: The starting dose is one 25 mg tablet at night, which can be increased to two or three 25 mg tablets if needed. For allergic conditions, Allphen may be taken two or three times a day, starting with one or two 10 mg tablets and adjusting as necessary.
Elderly: No specific dosage recommendations.
Children: Allphen is better to use the elixir form, which has 5 mg per 5 ml.
For allergies:
- Children 2-5 years: 5-15 mg
- Children 5-10 years: 10-25 mg
For sedation:
- Children 2-5 years: 15-20 mg
- Children 5-10 years: 20-25 mg
The dose should be given at night.
Interaction
Allphen may increase the effects of other medications that affect the nervous system, such as anticholinergics, antidepressants, sedatives, and alcohol. Allphen can also interfere with urine pregnancy tests, causing false results. Allphen should be stopped at least 72 hours before skin allergy tests as Allphen may affect the response, leading to false-negative results.
Contraindications
Allphen is not recommended for children under two years old or for those who are allergic to Allphen or any of its ingredients. Allphen should not be used in patients in a coma or those with severe depression of the nervous system. Allphen should not be given to premature infants or neonates. Allphen must be avoided by patients who have taken monoamine oxidase inhibitors in the last 14 days.
Side Effects
Possible side effects include drowsiness, dizziness, headaches, muscle spasms, or involuntary movements of the face. In rare cases, a severe condition called neuroleptic malignant syndrome (NMS) may occur, which requires immediate medical attention. Other effects can include allergic reactions, skin sensitivity to light, loss of appetite, stomach discomfort, dry mouth, blurred vision, blood problems, urinary issues, and confusion in young children. More serious issues like irregular heartbeats and liver problems can also occur.
Pregnancy & Lactation
Allphen is generally considered safe during pregnancy, though Allphen should only be used if the doctor thinks Allphen’s absolutely necessary. Allphen is not recommended in the two weeks before delivery because Allphen may cause irritability and excitement in the newborn. Allphen should be avoided during late pregnancy as Allphen could cause neurological problems in the infant. Allphen can pass into breast milk and may cause irritability in the baby.
Precautions & Warnings
Allphen should be avoided in children with signs of Reye’s syndrome. Use with caution in people with lung conditions, heart disease, narrow-angle glaucoma, epilepsy, liver or kidney issues, or bladder problems. Allphen should be used carefully in patients with certain stomach issues or blockages.
Overdose Effects
Overdose symptoms vary but can include confusion, dizziness, excitement, and in severe cases, coma. Children may experience excitation, incoordination, or hallucinations. Adults may become drowsy and may experience convulsions. Treatment typically involves supportive care, and convulsions should be treated with appropriate medications.
Therapeutic Class
Anti-emetic drugs, Miscellaneous sedatives & hypnotics, Sedating Anti-histamine
Storage Conditions
Store in a cool, dry place, away from light. Keep out of reach of children and use before the expiry date. Dispense only with a doctor’s prescription.
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