Amdopril 5/10
Form: Capsule
Strength: 5mg+10mg
Generic Name: Amlodipine + Benazepril Hydrochloride
Company: Beximco Pharmaceuticals Ltd.
MRP:৳ 6.0 (Capsule)
Is Antibiotic: No
Indications
Amdopril 5/10 is used to treat high blood pressure (hypertension). This combination medicine is not meant for the first treatment of hypertension.
Pharmacology
Amdopril 5/10 is a combination of two medicines, Amlodipine and Benazepril, used to lower high blood pressure. Benazepril works by blocking an enzyme that causes blood vessels to tighten. This helps lower blood pressure. Amlodipine is a calcium blocker that helps relax the blood vessels and reduce blood pressure. Both medicines work together to lower blood pressure and improve blood flow. After taking the medicine, Benazepril reaches its highest level in the blood in about 0.5-2 hours, while Amlodipine peaks in 6-12 hours. The effects last for 24 hours, with a blood pressure drop of about 10-25 mmHg (systolic) and 6-13 mmHg (diastolic).
Dosage & Administration
Adults: Take 2.5-10 mg of Amlodipine and 10-80 mg of Benazepril once a day. The doctor may adjust the dose based on the patient’s condition.
Starting Therapy: Amdopril 5/10 is best to start therapy with this combination after other treatments have not worked or if the patient has problems with swelling from Amlodipine.
Replacement Therapy: For convenience, patients can switch from separate pills of Amlodipine and Benazepril to this combination capsule.
Interaction
Amdopril 5/10 may interact with diuretics (water pills) and potassium supplements. If taken together, potassium levels should be monitored. Amdopril 5/10 can also be safely used with other medicines like beta-blockers, diuretics, and calcium blockers.
Contraindications
Amdopril 5/10 should not be used by patients who are allergic to Benazepril, Amlodipine, or any other ACE inhibitors.
Side Effects
Common side effects include cough, headache, dizziness, and swelling. The swelling is usually less when taking this combination compared to Amlodipine alone. Other rare side effects include allergic reactions, fatigue, stomach problems, and muscle pain.
Pregnancy & Lactation
Amdopril 5/10 should not be used during pregnancy, especially in the first trimester. If you are breastfeeding or planning to get pregnant, consult your doctor before using this medication.
Precautions & Warnings
Amdopril 5/10 should be used with caution in patients with kidney or liver problems. If you are having surgery, inform your doctor that you are taking this medication.
Overdose Effects
In case of overdose, symptoms may include severe dizziness, low blood pressure, or fainting. If overdose occurs, seek medical help immediately.
Therapeutic Class
Amdopril 5/10 belongs to the class of combined antihypertensive preparations.
Storage Conditions
Store below 25°C, away from light and moisture. Keep out of reach of children.
Similar Brands of Amlodipine + Benazepril Hydrochloride (Capsule – 5mg+10mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Amlozep 5/10 | Capsule | 5mg+10mg | Beacon Pharmaceuticals Ltd. | 6.04 |
| Amocal BZ 5/10 | Capsule | 5mg+10mg | Opsonin Pharma Limited | 6.02 |
| Benadip 5/10 | Capsule | 5mg+10mg | Incepta Pharmaceuticals Ltd. | 6.0 |
| Lodiben 5/10 | Capsule | 5mg+10mg | Eskayef Pharmaceuticals Ltd. | 6.0 |