Barinib 4
Form: Tablet
Strength: 4mg
Generic Name: Baricitinib
Company: Drug International Ltd.
MRP:৳ 40.0 (Box=10)
Per Piece: ৳ 4.00
Is Antibiotic: No
Indications
Barinib 4 is used to treat adult patients with moderate to severe Rheumatoid Arthritis who have not responded well to one or more tumor necrosis factor (TNF) inhibitor therapies.
Pharmacology
Barinib 4 is a selective and reversible inhibitor of Janus kinase JAK1 and JAK2. These enzymes help transmit signals inside the cell from surface receptors of cytokines and growth factors that are important for blood cell production, inflammation, and immune function. By partially inhibiting JAK1 and JAK2, Barinib 4 helps reduce the activation of STATs (which control gene expression) and reduces inflammation in the body.
Dosage & Administration
Adult dose: The recommended dose is 2 mg once a day. Barinib 4 can be used alone or with Methotrexate or other Disease-modifying antirheumatic drugs (DMARDs). Barinib 4 can be taken with or without food.
Pediatric Use: The safety and effectiveness of Barinib 4 in children have not been established.
Geriatric Use: Elderly patients may have reduced kidney function, so the dose should be adjusted accordingly.
Hepatic Impairment: No dose adjustment is needed for patients with mild or moderate liver impairment.
Renal impairment: Barinib 4 is not recommended for use in patients with a kidney function of less than 60 mL/min/1.73 m².
Interaction
When taken with strong OAT3 inhibitors like probenecid, the level of Barinib 4 in the body increases.
Barinib 4 has not been studied when used with other JAK inhibitors or biologic DMARDs.
Contraindications
Anemia: Do not start or stop Barinib 4 in patients with hemoglobin levels less than 8 g/dL.
Lymphopenia: Do not start or stop Barinib 4 in patients with an Absolute Lymphocyte Count lower than 500 cells/mm³.
Neutropenia: Do not start or stop Barinib 4 in patients with an Absolute Neutrophil Count lower than 1000 cells/mm³.
Side Effects
The most common side effects are increased LDL cholesterol (33.6%), upper respiratory tract infections (14.7%), and nausea (2.8%).
Pregnancy & Lactation
Barinib 4 is not recommended during pregnancy. There is no information on its presence in human milk.
Precautions & Warnings
Serious Infections: Do not use Barinib 4 in patients with serious infections, including localized infections.
Tuberculosis: Barinib 4 should not be given to patients with active tuberculosis.
Malignancy: Consider the risks and benefits before using Barinib 4 in patients with known cancer (other than successfully treated non-melanoma skin cancer) or if the patient develops cancer during treatment.
Thrombosis: Barinib 4 should be used carefully in patients at risk of blood clots.
Gastrointestinal Perforations: Use Barinib 4 with caution in patients at risk of bowel perforations.
Barinib 4 should only be dispensed with a prescription from a registered doctor.
Overdose Effects
If there is an overdose, patients should be monitored for any adverse reactions and treated accordingly.
Therapeutic Class
Barinib 4 is an Immunosuppressant.
Storage Conditions
Store Barinib 4 at or below 30°C, away from light and moisture. Keep Barinib 4 out of the reach of children.
Similar Brands of Baricitinib (Tablet – 4mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Baricent 4 | Tablet | 4mg | Incepta Pharmaceuticals Ltd. | 40.0 |
| Baricit 4 | Tablet | 4mg | Delta Pharma Limited | 30.0 |
| Barri 4 | Tablet | 4mg | Beximco Pharmaceuticals Ltd. | 40.0 |