Corazon 5
Form: Tablet
Strength: 5mg
Generic Name: Vericiguat
Company: Eskayef Pharmaceuticals Ltd.
MRP:৳ 75.0 (Box=10)
Per Piece: ৳ 7.50
Is Antibiotic: No
Indications
Corazon 5 is used to reduce the risk of heart-related deaths and hospital visits due to heart failure in adults with chronic heart failure. This includes patients with an ejection fraction of less than 45% who have been recently hospitalized or need outpatient diuretics.
Pharmacology
Corazon 5 is a stimulator of soluble guanylate cyclase (sGC), an enzyme involved in the nitric oxide (NO) signaling pathway. This helps increase the levels of cyclic GMP (cGMP) inside the body, which helps relax smooth muscles and dilate blood vessels. In heart failure, the NO and sGC systems are less active, which contributes to heart and blood vessel problems. By stimulating sGC, Corazon 5 helps restore normal function and reduces symptoms.
Dosage & Administration
Recommended Starting Dose: Take 2.5 mg orally once a day with food. The dose may be increased every two weeks to reach 10 mg per day, depending on how well the patient tolerates Corazon 5.
Geriatric Patients: No dosage change is needed for older adults. There is no significant difference in safety between older and younger patients, although older patients may be more sensitive to the medication.
Hepatic Impairment: No dosage adjustment is necessary for patients with mild to moderate liver problems.
Renal Impairment: No dosage change is required for patients with kidney function above 15 mL/min. Corazon 5 has not been studied in patients with severely impaired kidney function or those on dialysis.
Use in Children & Adolescents: Its safety and effectiveness have not been studied in children.
Interaction
Other Soluble Guanylate Cyclase Stimulators: Corazon 5 should not be used with other soluble guanylate cyclase stimulators.
PDE-5 Inhibitors: Do not use with PDE-5 inhibitors because Corazon 5 may cause low blood pressure.
With food & others: Corazon 5 should be taken with food, as this improves its absorption.
Contraindications
Corazon 5 is contraindicated in patients who are using other soluble guanylate cyclase stimulators.
Side Effects
Common side effects include low blood pressure and low red blood cell count (anemia).
Pregnancy & Lactation
Pregnancy: Corazon 5 is contraindicated during pregnancy because Corazon 5 may harm the fetus. Women should confirm they are not pregnant before starting treatment and use effective contraception during treatment and for one month after stopping the medication.
Nursing Mothers: There is no information about its presence in breast milk, but due to potential risks for breastfed infants, Corazon 5 should not be used while breastfeeding.
Precautions & Warnings
Corazon 5 should not be used during pregnancy. Women should be tested for pregnancy before starting treatment and use effective contraception during treatment and for one month after stopping the medication.
Overdose Effects
Overdose may cause low blood pressure. In case of overdose, symptomatic treatment is recommended. Vericiguat is unlikely to be removed by hemodialysis due to its high protein binding.
Therapeutic Class
Corazon 5 is a stimulator of soluble guanylate cyclase.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of the reach of children.
Similar Brands of Vericiguat (Tablet – 5mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Capazi 5 | Tablet | 5mg | Incepta Pharmaceuticals Ltd. | 50.0 |
| Corlift 5 | Tablet | 5mg | Ziska Pharmaceuticals Ltd. | 50.0 |
| Verigat 5 | Tablet | 5mg | The ACME Laboratories Ltd. | 52.0 |