Cotrimoxazole 480
Form: Tablet
Strength: 400mg+80mg
Generic Name: Sulphamethoxazole + Trimethoprim (Co-trimoxazole)
Company: Popular Pharmaceuticals Ltd.
MRP:৳ 1.48 (Tablet)
Is Antibiotic: Yes
Indications
Cotrimoxazole 480 is used to treat various infections caused by bacteria, including respiratory tract infections like bronchitis, pneumonia, and sinusitis. Cotrimoxazole 480 is also used for genito-urinary infections, such as urinary tract infections and gonorrhoea, as well as gastrointestinal infections caused by certain bacteria. Cotrimoxazole 480 is also used for infections like osteomyelitis, skin infections, and some parasitic infections.
Pharmacology
Cotrimoxazole 480 is a combination of two drugs, Trimethoprim and Sulphamethoxazole, which work together to block bacterial enzymes, stopping the production of folic acid in the bacteria, leading to their death. This combination is effective against a wide range of bacteria and some protozoa.
Dosage & Administration
For individuals over 12 years:
For mild to moderate infections: 1 tablet twice a day.
For severe infections: 1.5 tablets twice a day.
For long-term therapy (more than 14 days): 0.5 tablet twice a day.
For gonorrhoea: 2 tablets every 12 hours for 2 days or 2.5 tablets followed by another dose after 8 hours.
For individuals under 12 years (Suspension form):
6-12 years: 2 teaspoonfuls twice a day.
6 months-5 years: 1 teaspoonful twice a day.
6 weeks-6 months: 0.5 teaspoonful twice a day.
Interaction
There are no known significant interactions.
Contraindications
Cotrimoxazole 480 is contraindicated in patients who are allergic to trimethoprim or sulphonamides, or those with folate deficiency, severe liver or kidney problems, or certain blood conditions.
Side Effects
Cotrimoxazole 480 may cause mild side effects like headache, nausea, vomiting, or feeling unwell. Rare side effects include skin reactions, blood disorders, and allergic reactions. Most of these side effects are mild and temporary.
Pregnancy & Lactation
Cotrimoxazole 480 should not be used during pregnancy or breastfeeding, as Cotrimoxazole 480 can pass to the baby and cause harm, such as jaundice or kernicterus.
Precautions & Warnings
Cotrimoxazole 480 should be used with caution in patients with diabetes or those taking certain diabetes medications. Long-term use can lead to a type of anemia, which can be treated with folinic acid. Cotrimoxazole 480 is also important to monitor for signs of low folate levels, especially during prolonged treatment.
Overdose Effects
No specific information is available for overdose effects.
Therapeutic Class
Cotrimoxazole 480 belongs to the class of anti-diarrhoeal antimicrobial drugs, sulphonamides, and trimethoprim.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Similar Brands of Sulphamethoxazole + Trimethoprim (Co-trimoxazole) (Tablet – 400mg+80mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Alcot | Tablet | 400mg+80mg | Pacific Pharmaceuticals Ltd. | 1.0 |
| Bactipront | Tablet | 400mg+80mg | Renata Limited | 1.48 |
| Biotrim | Tablet | 400mg+80mg | Biopharma Ltd. | 1.49 |
| Cotrazen | Tablet | 400mg+80mg | Zenith Pharmaceuticals Ltd. | 1.4 |
| Cotrimox | Tablet | 400mg+80mg | Indo-Bangla Pharmaceuticals Ltd. | 1.35 |
| Cotrim | Tablet | 400mg+80mg | Square Pharmaceuticals Ltd. | 1.49 |
| Ditrim | Tablet | 400mg+80mg | Drug International Ltd. | 2.01 |
| Doctrim | Tablet | 400mg+80mg | Doctor’s Chemicals Works Ltd. | 1.02 |
| Fisat | Tablet | 400mg+80mg | Sanofi Bangladesh Ltd. | 1.51 |
| Gentrim | Tablet | 400mg+80mg | General Pharmaceuticals Ltd. | 1.49 |
| Jasotrim | Tablet | 400mg+80mg | Jayson Pharmaceuticals Ltd. | 1.49 |
| Litrim | Tablet | 400mg+80mg | Millat Pharmaceuticals Ltd. | 2.02 |
| Meditrim | Tablet | 400mg+80mg | Medimet Pharmaceuticals Ltd. | 1.48 |
| Neoset | Tablet | 400mg+80mg | Alco Pharma Limited | 1.42 |
| Politrim | Tablet | 400mg+80mg | The ACME Laboratories Ltd. | 1.43 |
| Septra | Tablet | 400mg+80mg | Asiatic Laboratories Ltd. | 1.49 |
| Servitrim | Tablet | 400mg+80mg | Novartis (Bangladesh) Ltd. | 1.42 |
| Sitrim | Tablet | 400mg+80mg | Silva Pharmaceuticals Ltd. | 2.0 |
| Sulprim | Tablet | 400mg+80mg | Somatec Pharmaceuticals Ltd. | 2.0 |
| Trimoprim | Tablet | 400mg+80mg | Beximco Pharmaceuticals Ltd. | 0.0 |