Crisa
Form: Ointment
Strength: 2% w/w
Generic Name: Crisaborole topical
MRP:৳ 500.0 (10gmTube)
Is Antibiotic: No
Indications
Crisa is used to treat mild to moderate atopic dermatitis in children 3 months of age and older.
Pharmacology
The active ingredient, Crisaborole, is a type of medicine that blocks an enzyme called phosphodiesterase 4B (PDE4B), which causes inflammation. Crisa is a chemical compound with a boron atom that helps Crisa penetrate the skin. By blocking PDE4B, Crisa reduces the release of certain proteins involved in inflammation and immune responses, such as tumor necrosis factor alpha (TNFα), interleukins (IL-12 and IL-23), and other cytokines.
Dosage & Administration
Apply a thin layer of Crisaborole twice daily to the affected areas. Crisa is for topical use only and should not be used in the eyes, mouth, or vagina.
Interaction
Studies show that Crisaborole and its metabolite 1 are not expected to interfere with the liver enzymes involved in drug metabolism (cytochrome P450), such as CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4.
Contraindications
No known contraindications.
Side Effects
Crisa may cause allergic reactions such as hives, itching, swelling, or redness at the application site. The most common side effect is pain at the application site, like burning or stinging.
Pregnancy & Lactation
There is no available data on the use of Crisaborole in pregnant women. In animal studies, no harmful effects were seen with oral Crisaborole during pregnancy. For lactation, there is no information on whether Crisaborole passes into human breast milk, so Crisa’s unclear if Crisa could affect a breastfeeding infant.
Precautions & Warnings
Some people may have hypersensitivity reactions, such as contact urticaria (a type of rash). If any allergic symptoms occur, stop using Crisaborole and seek medical help immediately.
Overdose Effects
No known overdose effects.
Therapeutic Class
Topical anti-inflammatory preparations.
Storage Conditions
Store below 30°C, away from light, and out of reach of children.