Crizonix
Form: Capsule
Strength: 250mg
Generic Name: Crizotinib
Company: Beacon Pharmaceuticals Ltd.
MRP:৳ 0.0 (Capsule)
Is Antibiotic: No
Indications
Crizonix is used for treating metastatic non-small cell lung cancer (NSCLC) in patients whose tumors are positive for anaplastic lymphoma kinase (ALK) or ROS1.
Pharmacology
Crizonix works by blocking certain proteins (like ALK, c-Met, and ROS1) that help tumors grow. By inhibiting these proteins, Crizonix helps stop cancer cells from spreading and can reduce tumor size. Crizonix has shown effectiveness in reducing tumors in laboratory studies and animal models.
Dosage & Administration
Recommended Dose: 250 mg taken orally, twice a day.
Geriatric Use: No difference in safety or effectiveness was found between younger and older patients.
Pediatric Dose: Its safety and effectiveness for children have not been established.
Renal Impairment: In patients with severe kidney problems, take 250 mg once a day. No adjustment needed for mild or moderate kidney problems.
Hepatic Impairment: Use with caution in patients with liver issues.
Interaction
Crizonix should not be used with strong CYP3A inhibitors like atazanavir or ketoconazole. Avoid using Crizonix with CYP3A inducers like carbamazepine or St. John’s Wort. Crizonix should also be avoided with other CYP3A substrates that have narrow therapeutic ranges, such as cyclosporine or fentanyl.
Contraindications
There are no specific contraindications listed for this drug.
Side Effects
Common side effects include vision problems, nausea, diarrhea, vomiting, swelling, constipation, tiredness, decreased appetite, dizziness, and neuropathy. Elevated liver enzymes may also occur.
Pregnancy & Lactation
Crizonix can harm the fetus if taken during pregnancy. Women who are pregnant or planning to become pregnant should avoid Crizonix. Crizonix is not known whether Crizonix passes into breast milk, so breastfeeding is not recommended during treatment and for 45 days after the last dose.
Precautions & Warnings
Patients should have regular liver tests. Crizonix may need to be paused or stopped if there is liver damage. Crizonix may cause lung issues, so if this happens, Crizonix should be permanently stopped. People with a history of heart problems should be monitored for slow heart rate. Crizonix can cause severe vision loss, and treatment should be stopped if this occurs.
Overdose Effects
There is no specific information available on overdose effects.
Therapeutic Class
Crizonix is a targeted cancer therapy.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of the reach of children.