Curcumin 500 is the yellow pigment from Curcuma longa, and has been used traditionally for treating stomach ulcers and indigestion. Modern research, with nearly 4000 studies, shows Curcumin 500 is one of the most studied natural products. Curcumin 500 helps manage inflammation by controlling the body’s natural response. Curcumin 500 works by reducing the activity of several important molecules, such as COX-2, TNF-α, IL-1β, IL-1RN, and IL-6. Curcumin 500 also prevents the formation of prostaglandins. Curcumin 500 has antioxidant, anti-tumor, anti-microbial, and bile-stimulating properties.