Curon
Form: Injection
Strength: 10mg/ml
Generic Name: Vecuronium Bromide
Company: EDCL
MRP:৳ 200.0 (10mg vial)
Is Antibiotic: No
Indications
Curon is used during general anaesthesia to help with inserting a tube into the windpipe (endotracheal intubation) and to relax the muscles during surgery or mechanical ventilation.
Pharmacology
Curon is a non-depolarizing neuromuscular blocking agent. Curon works by blocking the signals between the nerve endings and the muscles, preventing the muscles from contracting. Curon does this by competing with acetylcholine for the same receptors on the muscle cells.
Dosage & Administration
Adults and Elderly: The recommended starting dose is 0.08 to 0.10 mg per kg of body weight given through an injection. This will help make intubation easier in about 2.5 to 3 minutes. For caesarean sections or neonatal surgeries, the dose should not exceed 0.1 mg per kg.
Pediatric Patients: In babies and children under 4 months, a test dose of 0.01 to 0.02 mg per kg is recommended, and further doses are adjusted until 90% to 95% muscle relaxation is achieved. For children over 5 months, the usual dose is 0.08-0.1 mg per kg, and maintenance is adjusted according to their response.
Overweight and Obese Patients: Doses should be reduced based on ideal body weight, with initial doses ranging from 0.15 mg to 0.30 mg per kg body weight.
Interaction
Using succinylcholine before this medicine can make the blocking effect stronger and last longer. Inhalational anesthetics, like enflurane, isoflurane, and halothane, can also enhance the muscle relaxant effects. Certain antibiotics, like aminoglycosides and tetracyclines, can make the muscle relaxant effects stronger too. Other medications and conditions that affect the muscles or electrolyte balance can also interact with Curon.
Contraindications
Curon should not be used in patients with severe muscle weakness or allergies to any of the ingredients. Caution should be taken for those with a history of breathing problems or other serious medical conditions.
Side Effects
Common side effects include temporary muscle weakness, difficulty breathing, or allergic reactions. In rare cases, Curon may cause prolonged paralysis or muscle soreness after the drug wears off.
Pregnancy & Lactation
Pregnant or breastfeeding women should consult their doctor before using this drug. Curon is only recommended for use during pregnancy when absolutely necessary and under medical supervision.
Precautions & Warnings
Caution is needed for patients who may have too much iron in their bodies or certain blood disorders. If the treatment doesn’t seem to be working, doctors may need to check for other causes of muscle weakness or breathing problems.
Overdose Effects
Overdose symptoms may include severe muscle weakness, difficulty breathing, low blood pressure, and even loss of consciousness. Immediate medical attention is required if overdose is suspected.
Therapeutic Class
Curon is classified as a neuromuscular blocking agent used for muscle relaxation during surgeries.
Storage Conditions
Store Curon in a cool, dry place below 30°C, away from light and moisture. Keep Curon out of the reach of children.
Similar Brands of Vecuronium Bromide (Injection – 10mg/ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Nor Q | Injection | 10mg/ml | Incepta Pharmaceuticals Ltd. | 280.0 |
| Survec | Injection | 10mg/ml | Healthcare Pharmaceuticals Ltd. | 350.0 |
| Vencuron | Injection | 10mg/ml | Techno Drugs LTD. | 185.0 |
| Vencur | Injection | 10mg/ml | Popular Pharmaceuticals Ltd. | 280.0 |