Cytogem Inj
Form: Injection
Strength: 1gm/vial
Generic Name: Gemcitabine
Company: Drug International Ltd.
MRP:৳ 4500.0 (Injection)
Is Antibiotic: No
Indications
Cytogem Inj is used in the treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer, and ovarian cancer. Cytogem Inj is given along with other medications to treat these types of cancers, including locally advanced or metastatic stages. Cytogem Inj is also used for palliative care in certain patients with advanced lung cancer or pancreatic cancer.
Pharmacology
Cytogem Inj is broken down in the body to form two active substances that help block DNA synthesis. These substances reduce the availability of building blocks needed to form DNA, stopping the cancer cells from growing. Cytogem Inj works by preventing DNA from being formed properly, causing cancer cells to stop dividing and leading to their death (apoptosis).
Dosage & Administration
Non-Small Cell Lung Cancer: For single-agent use, the recommended dose is 1000 mg/m2 given by intravenous infusion once a week for three weeks, followed by a one-week break. For combination use with Cisplatin, doses are adjusted based on the regimen being followed (three-week or four-week cycle).
Pancreatic Cancer: The recommended dose is 1000 mg/m2, given once a week for seven weeks, followed by a one-week rest period. After this, the treatment continues with weekly doses for three weeks every four weeks.
Bladder Cancer: The recommended dose is 1250 mg/m2, given on days 1, 8, and 15 of each 28-day cycle. For combination therapy with Cisplatin, the dose is reduced and given alongside Cisplatin on day 1 of each cycle.
Breast Cancer: When used with Paclitaxel, Gemcitabine is given on days 1 and 8 of each 21-day cycle. Paclitaxel is given on day 1 before Gemcitabine.
Ovarian Cancer: Gemcitabine is combined with Carboplatin and given on days 1 and 8 of each 21-day cycle, followed by Carboplatin on day 1.
Interaction
No confirmed drug interactions have been reported, and no specific drug interaction studies have been conducted for Cytogem Inj.
Contraindications
Cytogem Inj should not be used by patients who are allergic to Gemcitabine or any of its ingredients.
Side Effects
Common side effects include blood cell count issues (such as low white blood cells, red blood cells, and platelets), liver enzyme changes, nausea, vomiting, diarrhea, and fatigue. Serious side effects may include lung and kidney problems. In rare cases, allergic reactions, including skin rashes, may occur.
Pregnancy & Lactation
Cytogem Inj is not recommended during pregnancy unless absolutely necessary. Cytogem Inj is not known if Cytogem Inj passes into breast milk, so Cytogem Inj is advised to avoid breastfeeding while using this medicine.
Precautions & Warnings
Cytogem Inj should be used with caution in patients at risk of severe side effects, such as myelosuppression, lung toxicity, liver issues, and renal failure. Cytogem Inj may also cause harm to the unborn child and should be avoided if pregnant.
Overdose Effects
Overdose symptoms may include severe effects on blood cell counts, skin reactions, and possible damage to organs. If an overdose occurs, supportive therapy should be given, and blood counts should be monitored closely.
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store in the original carton at room temperature (20° to 25°C), away from light. Do not refrigerate as crystallization may occur. Keep out of the reach of children.
Similar Brands of Gemcitabine (Injection – 1gm/vial)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Gembine Inj. 1 gm | Injection | 1gm/vial | Healthcare Pharmaceuticals Ltd. | 5500.0 |
| Gemcitabine PhaRes | Injection | 1gm/vial | ZAS Corporation | 7025.0 |
| Gemoxen | Injection | 1gm/vial | Beacon Pharmaceuticals Ltd. | 6000.0 |
| Gemzar | Injection | 1gm/vial | Eli Lilly and Company | 8732.0 |