D-Vine
Form: Injection
Strength: 200000 IU/ml
Generic Name: Cholecalciferol
Company: Healthcare Pharmaceuticals Ltd.
MRP:৳ 120.0 (1ml ampoule)
Is Antibiotic: No
Indications
D-Vine is used to treat vitamin D3 deficiency, which can occur in people who don’t get enough sunlight or those who have a diet low in vitamin D3. Vitamin D3 helps the body absorb calcium and phosphate, which are important for healthy bones and teeth. D-Vine can help prevent conditions like rickets, osteomalacia, and osteoporosis. D-Vine is also important during pregnancy and breastfeeding to prevent pre-eclampsia and support the growth of the baby. Additionally, D-Vine boosts immunity.
Pharmacology
The active form of Vitamin D3, called Calcitriol, works by attaching to Vitamin D receptors (VDRs) in various tissues. Vitamin D3 is fat-soluble and has a half-life of around 50 days. D-Vine is absorbed in the small intestine and carried to the liver where D-Vine is changed into 25-hydroxy Vitamin D3 (Calcidiol). This is further converted in the kidney to 1,25-dihydroxy Vitamin D3 (Calcitriol), which helps the body absorb calcium. Any unprocessed Vitamin D3 is stored in fat and muscles. Vitamin D3 is eliminated from the body through feces and urine.
Dosage & Administration
Adults: For Vitamin D3 deficiency, take 40,000 IU once a week for 7 weeks. For maintenance, take 1,400-2,000 IU per day. To check if the target vitamin D level has been reached, test levels 3-4 months after starting maintenance. To prevent deficiency, take 20,000 IU every 4 weeks, or higher doses as needed. For osteoporosis, take 20,000 IU once a month.
Children (12-18 years): For deficiency, take 20,000 IU every two weeks for 6 weeks. To prevent deficiency, take 20,000 IU every 6 weeks.
For film-coated tablets: Take 1,000 IU (1-2 tablets) daily, or as directed by your doctor. Take with food or within one hour after eating.
For chewable tablets: Take 1,000-2,000 IU daily, or as directed by your doctor. Take with food or within one hour after eating. Chew the tablet before swallowing.
For syrup: For patients at risk of Vitamin D3 deficiency, infants aged 0-1 year should take 400 IU/day (2 ml), and children over 1 year should take 600 IU/day (3 ml). For those with deficiency, infants 0-1 year should take 2,000 IU/day (+50,000 IU/week) for 6 weeks, and children aged 1-18 years should take 2,000 IU/day for 6 weeks.
For injection: Infants receiving Vitamin D-enriched milk should take ½ ampoule (0.5 ml, 100,000 IU) every 6 months. Other infants or young children up to 5 years should take 1 ampoule (1 ml, 200,000 IU) every 6 months. Adolescents should take 1 ampoule (1 ml, 200,000 IU) every 6 months during winter. Pregnant women should take ½ ampoule (0.5 ml, 100,000 IU) from the 6th or 7th month of pregnancy. Elderly individuals should take ½ ampoule (0.5 ml, 100,000 IU) every 3 months.
For Vitamin D deficiency, 1 ampoule (1 ml, 200,000 IU) can be repeated after 1 to 6 months, as directed by the doctor.
Interaction
Some medications can reduce the effectiveness of Vitamin D3 by interfering with its absorption or metabolism. These include magnesium-containing antacids, digoxin, thiazide diuretics, cholestyramine, cholestipol, phenytoin, phenobarbital, orlistat, and mineral oil. Corticosteroids, such as prednisolone, can increase the body’s need for Vitamin D3.
Contraindications
D-Vine is not recommended for people with diseases that cause high levels of calcium in the blood. D-Vine is also not suitable for those who are allergic to Vitamin D3 or any of its ingredients or who have Vitamin D3 toxicity.
Side Effects
Side effects are rare, but they may include loss of appetite, tiredness, nausea, vomiting, diarrhea, constipation, weight loss, excessive urination, sweating, headache, thirst, dizziness, and high levels of calcium and phosphate in the blood and urine.
Pregnancy & Lactation
Studies have shown that doses up to 4,000 IU of Vitamin D3 are safe during pregnancy. The recommended daily intake is 400 IU, but higher doses may be needed for women who are deficient. Pregnant women should follow their doctor’s advice as their needs may vary. Vitamin D3 is passed into breast milk, but no overdose has been reported in infants. If additional Vitamin D3 is given to a breastfeeding baby, the mother’s total intake should be considered.
Precautions & Warnings
When taking high doses of Vitamin D3, calcium levels in the blood should be monitored regularly, especially in people with kidney problems or during pregnancy and breastfeeding. People taking digoxin or thiazide diuretics should consult a doctor before using Vitamin D3. Those with liver or kidney disease, hyperthyroidism, lymphoma, tuberculosis, or granulomatous diseases should also consult their doctor before use.
Overdose Effects
Taking too much Vitamin D3 can lead to a condition called hypervitaminosis D, where there is too much Vitamin D in the body, which can cause harmful effects.
Therapeutic Class
D-Vine is a Vitamin used in bone formation and a Vitamin D preparation.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of the reach of children.