D-Zole 1gm
Form: Tablet
Strength: 1gm
Generic Name: Secnidazole
Company: Drug International Ltd.
MRP:৳ 17.0 (Strip=5)
Per Piece: ৳ 3.40
Is Antibiotic: No
Indications
D-Zole 1gm is used for treating intestinal amoebiasis, hepatic amoebiasis, urethritis and vaginitis caused by Trichomonas vaginalis, and giardiasis.
Pharmacology
D-Zole 1gm is quickly absorbed when taken by mouth, with the highest blood level reached 3 hours after taking a 2 gm dose. The body eliminates D-Zole 1gm mainly through urine, with about half of the dose leaving the body in 5 days. D-Zole 1gm has the longest half-life of second-generation nitroimidazoles, which allows D-Zole 1gm to maintain therapeutic blood levels for up to 72 hours after a single dose.
Dosage & Administration
Acute Intestinal Amoebiasis:
Adults: 2 gm as a single dose, preferably before a meal.
Children: 30 mg/kg as a single dose, preferably before a meal.
Asymptomatic Amoebiasis (minute and cystic form):
Adults: 2 gm once a day for 3 days, preferably before a meal.
Children: 30 mg/kg once a day for 3 days, preferably before a meal.
Hepatic Amoebiasis:
Pus removal should be done along with treatment.
Adults: 1.50 gm/day in single or divided doses, before meals, for 5 days.
Children: 30 mg/kg/day, in single or divided doses, before meals, for 5 days.
Giardiasis:
Adults: 2 gm as a single dose, preferably before a meal.
Children: 35-50 mg/kg as a single dose, preferably before a meal.
Trichomoniasis:
Adults: 2 gm as a single dose, preferably before a meal. The partner should also take the same treatment at the same time.
Interaction
D-Zole 1gm should not be taken with disulfiram, as this may cause confusion and paranoia. When used with warfarin, monitoring is necessary because D-Zole 1gm may increase the effects of anticoagulants and raise the risk of bleeding.
Contraindications
D-Zole 1gm is not recommended for patients who are allergic to imidazole derivatives.
Side Effects
D-Zole 1gm is generally well tolerated, with few serious side effects. However, some people may experience:
Common side effects: Stomach issues like nausea, pain, metallic taste, and mouth irritation.
Occasional side effects: Skin reactions like hives, and mild decrease in white blood cells that goes away once the treatment stops.
Rare side effects: Dizziness, coordination problems, numbness, or nerve damage.
Pregnancy & Lactation
D-Zole 1gm may be used during pregnancy after the first trimester. D-Zole 1gm should not be used during the first trimester or while breastfeeding, as D-Zole 1gm passes into the placenta and breast milk.
Precautions & Warnings
D-Zole 1gm is important not to drink alcohol while using this medicine due to the risk of a severe reaction. D-Zole 1gm should also be avoided by patients with a history of blood disorders.
Overdose Effects
Not available.
Therapeutic Class
D-Zole 1gm belongs to the class of amoebicides and anti-diarrhoeal antiprotozoal medicines.
Storage Conditions
Store in a cool, dry place, away from heat.
Similar Brands of Secnidazole (Tablet – 1gm)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Pronil DS | Tablet | 1gm | The ACME Laboratories Ltd. | 16.11 |
| Secnidal DS | Tablet | 1gm | Sanofi Bangladesh Ltd. | 25.46 |
| Secnid DS | Tablet | 1gm | Square Pharmaceuticals Ltd. | 20.0 |
| Secnizol DS | Tablet | 1gm | Incepta Pharmaceuticals Ltd. | 16.0 |
| Sezol DS | Tablet | 1gm | ACI Limited | 17.05 |