Daconib 45
Form: Tablet
Strength: 45mg
Generic Name: Dacomitinib
Company: Everest Pharmaceuticals Ltd.
MRP:৳ 300.0 (Box=30)
Per Piece: ৳ 10.00
Is Antibiotic: No
Indications
Daconib 45 is used for the first-line treatment of metastatic non-small cell lung cancer (NSCLC) in patients who have specific genetic mutations in the epidermal growth factor receptor (EGFR) gene, such as exon 19 deletion or exon 21 L858R substitution, as identified by an FDA-approved test.
Pharmacology
Daconib 45 works by blocking the activity of EGFR and other related receptors (HER2 and HER4), which play a role in the growth of cancer cells. Daconib 45 can also block other proteins involved in cancer growth. Daconib 45 has been shown to stop cancer cell growth in mice with tumors caused by EGFR mutations, both in tumors outside and inside the brain.
Dosage & Administration
Recommended Dose: 45 mg taken once a day until the disease worsens or side effects become too severe. Daconib 45 can be taken with or without food, at the same time each day. If you miss a dose or vomit, do not take an extra dose—just continue with your next scheduled dose.
Dose Reduction: If needed, the dose can be reduced to 30 mg once a day, and further reduced to 15 mg once a day if necessary.
Interaction
Avoid taking Daconib 45 with proton pump inhibitors (PPIs). Instead, use antacids or H2-receptor antagonists. Also, make sure to take Daconib 45 at least 6 hours before or 10 hours after taking an H2-receptor antagonist.
Daconib 45 should not be taken with certain drugs that are processed by CYP2D6, as even small increases in their concentration can cause serious side effects.
Contraindications
There are no specific contraindications.
Side Effects
The most common side effects (affecting more than 20% of people) include diarrhea, rash, nail problems, mouth sores, loss of appetite, dry skin, weight loss, hair loss, cough, and itching.
Pregnancy & Lactation
Daconib 45 can harm a fetus if taken during pregnancy. Daconib 45 is also unknown whether Daconib 45 passes into breast milk, but due to possible serious side effects in infants, women should not breastfeed during treatment and for at least 17 days after the last dose.
Precautions & Warnings
If lung disease is confirmed, permanently stop the medication. If diarrhea or skin problems occur, reduce the dose based on severity. Daconib 45 can harm a fetus, so women should use effective contraception during treatment.
Overdose Effects
There are no specific overdose effects mentioned.
Therapeutic Class
Daconib 45 is a Cytotoxic Chemotherapy drug.
Storage Conditions
Store Daconib 45 below 30°C, away from light, and keep Daconib 45 out of reach of children.