Daunobin
Form: Injection
Strength: 20mg/4ml
Generic Name: Daunorubicin
Company: Healthcare Pharmaceuticals Ltd.
MRP:৳ 600.0 (4ml Vial)
Is Antibiotic: No
Indications
Daunobin is used with other approved anticancer drugs to help treat acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) in adults and acute lymphocytic leukemia in both children and adults.
Pharmacology
Daunobin works by stopping the growth of cancer cells in different ways. Daunobin binds to DNA and prevents certain enzymes from repairing DNA, which leads to breaks in the DNA strands. This damages the cancer cells and helps treat a variety of tumors.
Dosage & Administration
Adults: The drug is given intravenously on specific days, with dosages based on age and body size. For adults under 60, Daunobin is given 45 mg/m² on days 1, 2, and 3, along with cytosine arabinoside. For adults 60 and older, the dose is reduced to 30 mg/m² on the same days.
Pediatric patients: For children with acute lymphocytic leukemia, the dosage is based on body size, and the treatment typically lasts for several courses. Special calculations are made for younger children based on weight.
Interaction
Daunobin should not be used in patients who have had previous treatments with similar drugs like Doxorubicin, as this increases the risk of heart problems. Daunobin can also cause problems when taken with certain other medications like cyclophosphamide, methotrexate, or other myelosuppressive drugs.
Contraindications
Daunobin is contraindicated in patients who are allergic to Daunorubicin or any of its ingredients.
Side Effects
Side effects include damage to bone marrow, heart problems, hair loss, nausea, vomiting, mouth sores, diarrhea, and pain at the injection site. Rarely, allergic reactions, fever, and chills may occur. High uric acid levels can also be seen, especially in leukemia patients.
Pregnancy & Lactation
Daunobin should not be used during pregnancy unless absolutely necessary. Daunobin may pass into breast milk, so breastfeeding mothers should stop nursing while on this medication.
Precautions & Warnings
Close monitoring is needed while using this drug. Heart, kidney, and liver function should be checked before starting treatment. Daunobin may cause the urine to turn red temporarily. This drug must only be given by experienced healthcare providers in suitable medical settings, with proper measures in place to manage any serious side effects.
Overdose Effects
N/A
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store the drug in the refrigerator at 2°-8°C. Protect from light. If Daunobin comes in contact with skin or mucous membranes, wash the area thoroughly with soap and water. Proper disposal procedures should be followed for anticancer drugs.
Similar Brands of Daunorubicin (Injection – 20mg/4ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Dorubin | Injection | 20mg/4ml | Drug International Ltd. | 500.0 |
| Rubicin | Injection | 20mg/4ml | Beacon Pharmaceuticals Ltd. | 600.0 |