Dazine 1%
Form: Cream
Strength: 1%
Generic Name: Silver Sulfadiazine
Company: Alco Pharma Limited
MRP:৳ 381.14 (500gm pack)
Is Antibiotic: No
Indications
Dazine 1% is used to prevent bacterial infection in burn wounds. Dazine 1% can also be applied to manage wounds that are prone to infection, other than burns.
Pharmacology
Dazine 1% works by causing changes in the bacterial cell, weakening its membrane and reducing its ability to grow. The silver part of the medicine attaches to bacterial cells and stops them from dividing. Dazine 1% does not block the growth of healthy cells in the body. A small amount of Dazine 1% is absorbed into the body, mostly excreted in the urine. In children with burns, Dazine 1% may be absorbed more than in adults.
Dosage & Administration
Adults: Apply the cream to the burn wound once or twice a day. Reapply if the cream is removed due to activity or after hydrotherapy. Continue until the wound heals or is ready for a skin graft. If necessary, dressings can be used.
Pediatric patients: Safety and effectiveness in children have not been established.
Interaction
Dazine 1% may reduce the effect of enzymatic debriding agents. Dazine 1% can also increase the effects of certain diabetes medications and phenytoin in patients with large burns. If using Cimetidine with large burns, there may be an increased risk of low white blood cell count.
Contraindications
Dazine 1% should not be used by people who are allergic to Dazine 1% or any of its ingredients. Dazine 1% should also be avoided in pregnant women near term, premature infants, or newborn infants in the first 2 months of life.
Side Effects
Some patients may experience low white blood cell count. Other rare side effects include skin necrosis, rash, skin discoloration, a burning sensation, and kidney problems.
Pregnancy & Lactation
Dazine 1% is classified as Pregnancy Category B. Dazine 1% should only be used in pregnancy if absolutely necessary, especially for women near term. Dazine 1% is unclear whether Dazine 1% passes into breast milk. The decision to continue breastfeeding or stop the medication should be made by the doctor based on the mother’s needs.
Precautions & Warnings
Careful monitoring is needed if the liver or kidneys are not functioning well. If used with topical enzymes, there is a chance that silver may affect their effectiveness. Dazine 1% is important to monitor the blood levels of sulfadiazine and check for any kidney problems in patients with extensive burns.
Overdose Effects
N/A
Therapeutic Class
Topical Antibiotic
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of the reach of children.
Similar Brands of Silver Sulfadiazine (Cream – 1%)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Bentol 1% | Cream | 1% | Doctor’s Chemicals Works Ltd. | 28.0 |
| Bentol 1% | Cream | 1% | Doctor’s Chemicals Works Ltd. | 11.38 |
| Burnless Cream 250gm | Cream | 1% | Sharif Pharmaceuticals Ltd. | 225.68 |
| Burnsil 1% | Cream | 1% | Beximco Pharmaceuticals Ltd. | 45.0 |
| Dersa 1% | Cream | 1% | Marker Pharmaceuticals Ltd. | 0.0 |
| Eburn | Cream | 1% | Pacific Pharmaceuticals Ltd. | 50.0 |
| Flamzin | Cream | 1% | Cosmic Pharma Ltd. | 26.0 |
| G-Silver sulphadiazine | Cream | 1% | Gonoshasthaya Pharmaceuticals Ltd. | 30.0 |
| G-Silver sulphadiazine | Cream | 1% | Gonoshasthaya Pharmaceuticals Ltd. | 195.0 |
| Medizen | Cream | 1% | Pharmasia Ltd. | 11.54 |
| Medizen | Cream | 1% | Pharmasia Ltd. | 35.0 |
| Neozine 25gm | Cream | 1% | Opsonin Pharma Limited | 30.2 |
| Neozine 500gm | Cream | 1% | Opsonin Pharma Limited | 398.84 |
| Sibalyn | Cream | 1% | ACI Limited | 260.78 |
| Sibalyn Cream 25gm | Cream | 1% | ACI Limited | 40.12 |
| Silcream 1% | Cream | 1% | Jayson Pharmaceuticals Ltd. | 60.18 |
| Silcream 1% | Cream | 1% | Jayson Pharmaceuticals Ltd. | 300.9 |
| Silvadazin 1% | Cream | 1% | Aristopharma Limited | 60.0 |
| Silvazin 1% | Cream | 1% | Chemist Laboratories Ltd. | 0.0 |
| Silvec | Cream | 1% | Drug International Ltd. | 50.0 |
| Silverax | Cream | 1% | Healthcare Pharmaceuticals Ltd. | 60.0 |
| Silverzine 1% | Cream | 1% | Gaco Pharmaceuticals(G.A Company Ltd) | 45.0 |
| Silzin | Cream | 1% | Kemiko Pharmaceuticals Ltd. | 50.0 |