Deflux
Form: Pediatric Drops
Strength: 5mg/ml
Generic Name: Domperidone
Company: Beximco Pharmaceuticals Ltd.
MRP:৳ 20.0 (15ml drop)
Is Antibiotic: No
Indications
Deflux is used to treat symptoms like bloating, stomach discomfort, and indigestion. Deflux helps with nausea, vomiting, and heartburn. Deflux is also used for Parkinson’s disease-related nausea and to speed up barium movement in certain medical scans.
Pharmacology
Deflux is a medication that works by blocking certain receptors in the stomach and brain. This helps improve stomach movement, speeds up digestion, and reduces nausea. Deflux mostly works in the stomach, with little effect on the brain, so Deflux doesn’t cause mental side effects. Deflux also helps prevent stomach contents from coming back up.
Dosage & Administration
Adults: Take 10-20 mg (1-2 tablets or 10-20 ml suspension) every 6-8 hours. The maximum daily dose is 80 mg.
Children: Take 2-4 ml suspension per 10 kg of body weight every 6-8 hours.
For acute conditions: Adults take 20 mg (2 tablets or 20 ml suspension) every 6-8 hours. Children take 0.2-0.4 mg/kg of body weight every 6-8 hours.
By rectum (suppositories): Adults take 30-60 mg every 4-8 hours. Children (10-25 kg) take a maximum of 30 mg per day, divided if necessary. Treatment should not last longer than 12 weeks.
Interaction
Deflux should not be taken with certain antacids or anticholinergic drugs, as they reduce its effect. Deflux is processed in the body by a specific enzyme, so taking other medications that affect this enzyme may increase its level. Deflux can also influence the absorption of other oral medications, especially those with slow-release or special coatings.
Contraindications
Deflux should not be used by people who are allergic to Deflux or by newborns. Deflux should not be used in certain gastrointestinal problems, such as bleeding or blockages. Deflux is also not recommended for people with certain types of tumors in the pituitary gland.
Side Effects
Side effects are rare, but may include temporary stomach cramps, dizziness, or skin reactions like rashes. In very rare cases, Deflux may cause an increase in a hormone that can lead to milk production in both men and women, or swelling in men’s breasts. If used in infants or people with brain-related conditions, there could be a risk of neurological side effects.
Pregnancy & Lactation
Deflux has not caused birth defects in animals, but Deflux should only be used during pregnancy if absolutely necessary. Deflux passes into breast milk, so Deflux is not recommended for breastfeeding mothers unless the benefits outweigh the risks.
Precautions & Warnings
Deflux should be used cautiously in children and in people with liver problems. Young children may have a higher risk of certain side effects because their brain barrier isn’t fully developed.
Overdose Effects
Overdose symptoms may include drowsiness, confusion, or movement problems, especially in children. If an overdose occurs, activated charcoal and monitoring of the patient are recommended. Medications for movement problems may also be used if necessary.
Therapeutic Class
Deflux is a motility stimulant and a dopamine antagonist, used to help with stomach movement and related issues.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Similar Brands of Domperidone (Pediatric Drops – 5mg/ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Adorex | Pediatric Drops | 5mg/ml | Ambee Pharmaceuticals Ltd. | 20.07 |
| Apuldon | Pediatric Drops | 5mg/ml | Aristopharma Limited | 25.0 |
| Domin | Pediatric Drops | 5mg/ml | Opsonin Pharma Limited | 25.0 |
| Domiren | Pediatric Drops | 5mg/ml | Renata Limited | 25.0 |
| Don A | Pediatric Drops | 5mg/ml | The ACME Laboratories Ltd. | 25.0 |
| Dopadon Drop | Pediatric Drops | 5mg/ml | The Ibn Sina Pharmaceutical Ind. Ltd. | 30.0 |
| Dysnov | Pediatric Drops | 5mg/ml | Unimed Unihealth Pharmaceuticals Ltd. | 20.0 |
| Emidom | Pediatric Drops | 5mg/ml | Somatec Pharmaceuticals Ltd. | 20.08 |
| Esogut | Pediatric Drops | 5mg/ml | Biopharma Ltd. | 25.0 |
| Gutset | Pediatric Drops | 5mg/ml | Ad-din Pharmaceuticals Ltd. | 20.0 |
| Loridon | Pediatric Drops | 5mg/ml | Modern Pharmaceuticals Ltd. | 20.0 |
| Motigut Drop | Pediatric Drops | 5mg/ml | Square Pharmaceuticals Ltd. | 25.08 |
| Omidon Paediatric Drops | Pediatric Drops | 5mg/ml | Incepta Pharmaceuticals Ltd. | 25.0 |
| Perion | Pediatric Drops | 5mg/ml | Globe Pharmaceuticals Ltd. | 25.0 |
| Protix | Pediatric Drops | 5mg/ml | Apex Pharma Ltd. | 20.0 |
| Ridon | Pediatric Drops | 5mg/ml | Eskayef Pharmaceuticals Ltd. | 35.0 |
| Sandom | Pediatric Drops | 5mg/ml | Sanofi Bangladesh Ltd. | 20.13 |
| Vave PD | Pediatric Drops | 5mg/ml | ACI Limited | 25.8 |
| Virdon | Pediatric Drops | 5mg/ml | Virgo Pharmaceuticals Ltd. | 28.0 |
| Vomitop | Pediatric Drops | 5mg/ml | Navana Pharmaceuticals Ltd. | 25.0 |