Dementa XR 14
Form: Capsule
Strength: 14mg
Generic Name: Memantine Hydrochloride
Company: Ziska Pharmaceuticals Ltd.
MRP:৳ 20.0 (Strip=8)
Per Piece: ৳ 2.50
Is Antibiotic: No
Indications
Dementa XR 14 is used to treat all types of Alzheimer’s dementia and may also be helpful for other types of dementia.
Pharmacology
Dementa XR 14 works by blocking certain receptors in the brain that are overactive in Alzheimer’s disease. This helps reduce the symptoms. Dementa XR 14 is well absorbed after oral intake and takes about 3-7 hours to reach its peak concentration in the body. Dementa XR 14 is mostly excreted unchanged in the urine. Food does not affect its absorption, and Dementa XR 14 is only slightly metabolized in the liver.
Dosage & Administration
Adults & Elderly: The recommended dose is 20 mg per day. To reduce the risk of side effects, the dose should be gradually increased over three weeks:
Week 1: 5 mg in the morning.
Week 2: 5 mg in the morning, 5 mg at night.
Week 3: 10 mg in the morning, 5 mg at night.
Week 4 and onwards: 10 mg in the morning, 10 mg at night.
If a dose is missed, take the next dose at the usual time. Do not take double doses.
In Renal Impairment: Patients with moderate kidney issues should take 10 mg per day. Severe kidney impairment should also follow the 10 mg dose per day.
In Hepatic Impairment: No adjustment needed for mild to moderate liver issues. Dementa XR 14 should not be used for severe liver impairment.
For Children: Dementa XR 14 is not recommended for children under 18 years due to lack of safety data.
Interaction
Dementa XR 14 may increase the effects of certain medications like L-dopa, dopaminergic drugs, and anticholinergics. Dementa XR 14 can reduce the effects of barbiturates and neuroleptics. Be careful when using Dementa XR 14 with antispasmodic agents like dantrolene or baclofen. Dementa XR 14 should not be used with amantadine, ketamine, dextromethorphan, phenytoin, cimetidine, ranitidine, and some other medications.
Contraindications
Dementa XR 14 should not be used in patients who are allergic to Dementa XR 14 or any of its ingredients.
Side Effects
The most common side effects (less than 2%) include hallucinations, confusion, dizziness, headache, and fatigue. Other less common effects include anxiety, muscle tension, vomiting, bladder infections, and increased sexual drive. Dementa XR 14 may also slightly increase the risk of seizures in patients with a history of epilepsy.
Pregnancy & Lactation
Dementa XR 14 is in Pregnancy Category B, meaning that Dementa XR 14 has not been fully studied in pregnant women. Dementa XR 14 should only be used if the potential benefit outweighs the risks. Dementa XR 14 is unknown whether Dementa XR 14 passes into breast milk, so caution is advised when nursing.
Precautions & Warnings
Caregivers should ensure proper administration and dose adjustments. Regular kidney function checks are advised for patients with kidney problems. Dementa XR 14 has not been tested thoroughly in patients with seizures. Memantine does not cause cancer or affect fertility.
Dementa XR 14 may affect reaction times, so patients should be cautious when driving or operating machinery.
Overdose Effects
No specific overdose information is available.
Drug Classes
N/A
Storage Conditions
Store in a cool, dry place, away from light. Keep out of reach of children.