Doriject
Form: Injection
Strength: 500mg/vial
Generic Name: Doripenem
Company: Popular Pharmaceuticals Ltd.
MRP:৳ 2000.0 (Injection)
Is Antibiotic: No
Indications
Doriject is used to treat infections, including:
- Complicated abdominal infections caused by certain bacteria like E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and more.
- Complicated urinary tract infections, including kidney infections, caused by bacteria like E. coli, Klebsiella pneumoniae, and others.
Pharmacology
Doriject is a broad-spectrum antibiotic that works against many types of bacteria, both positive and negative. Doriject kills bacteria by stopping them from making their cell walls, which causes the bacteria to die.
Doriject works by attaching to certain proteins in bacteria, like in E. coli and P. aeruginosa, to stop the bacteria from maintaining their shape and function.
Dosage & Administration
Adults & Elderly: 500 mg every 8 hours by injection for 1 hour, or as directed by the doctor. In more serious cases, a higher dose may be needed.
Pediatric Patients: Not established for children.
Renal Impairment: The dosage may be adjusted depending on kidney function. Consult a doctor for proper dosing.
Interaction
Doriject can increase blood levels when taken with probenecid. Doriject may lower the levels of valproic acid, which could increase the risk of seizures.
Contraindications
Doriject should not be used by people who are allergic to any of its ingredients or other similar antibiotics, or who have had a severe allergic reaction to beta-lactam antibiotics.
Side Effects
Possible side effects include:
- Headache
- Diarrhea
- Nausea
- Inflammation at the injection site
- Rash
- Vulvar yeast infection
Pregnancy & Lactation
If pregnant or breastfeeding, talk to a doctor before using Doriject. Doriject should only be used during pregnancy if absolutely necessary, and Doriject is not known if Doriject passes into breast milk.
Precautions & Warnings
Doriject should be used carefully in people with a history of severe allergic reactions to antibiotics in the same group. If any severe reaction occurs, Doriject should be stopped immediately and treated.
Overdose Effects
No specific information available for overdose effects.
Therapeutic Class
Doriject belongs to the beta-lactam class of antibiotics.
Storage Conditions
Store Doriject away from light, moisture, and at temperatures below 25°C. Keep out of the reach of children.
Similar Brands of Doripenem (Injection – 500mg/vial)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Dorinem 500 | Injection | 500mg/vial | ACI Limited | 2006.02 |
| Doripen | Injection | 500mg/vial | Eskayef Pharmaceuticals Ltd. | 2000.0 |
| Perinem 500 | Injection | 500mg/vial | Drug International Ltd. | 2000.0 |