Doripen
Form: Injection
Strength: 500mg/vial
Generic Name: Doripenem
Company: Eskayef Pharmaceuticals Ltd.
MRP:৳ 2000.0 (Injection)
Is Antibiotic: No
Indications
Doripen is used to treat infections, including:
- Complicated abdominal infections caused by certain bacteria like E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and more.
- Complicated urinary tract infections, including kidney infections, caused by bacteria like E. coli, Klebsiella pneumoniae, and others.
Pharmacology
Doripen is a broad-spectrum antibiotic that works against many types of bacteria, both positive and negative. Doripen kills bacteria by stopping them from making their cell walls, which causes the bacteria to die.
Doripen works by attaching to certain proteins in bacteria, like in E. coli and P. aeruginosa, to stop the bacteria from maintaining their shape and function.
Dosage & Administration
Adults & Elderly: 500 mg every 8 hours by injection for 1 hour, or as directed by the doctor. In more serious cases, a higher dose may be needed.
Pediatric Patients: Not established for children.
Renal Impairment: The dosage may be adjusted depending on kidney function. Consult a doctor for proper dosing.
Interaction
Doripen can increase blood levels when taken with probenecid. Doripen may lower the levels of valproic acid, which could increase the risk of seizures.
Contraindications
Doripen should not be used by people who are allergic to any of its ingredients or other similar antibiotics, or who have had a severe allergic reaction to beta-lactam antibiotics.
Side Effects
Possible side effects include:
- Headache
- Diarrhea
- Nausea
- Inflammation at the injection site
- Rash
- Vulvar yeast infection
Pregnancy & Lactation
If pregnant or breastfeeding, talk to a doctor before using Doripen. Doripen should only be used during pregnancy if absolutely necessary, and Doripen is not known if Doripen passes into breast milk.
Precautions & Warnings
Doripen should be used carefully in people with a history of severe allergic reactions to antibiotics in the same group. If any severe reaction occurs, Doripen should be stopped immediately and treated.
Overdose Effects
No specific information available for overdose effects.
Therapeutic Class
Doripen belongs to the beta-lactam class of antibiotics.
Storage Conditions
Store Doripen away from light, moisture, and at temperatures below 25°C. Keep out of the reach of children.
Similar Brands of Doripenem (Injection – 500mg/vial)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Doriject | Injection | 500mg/vial | Popular Pharmaceuticals Ltd. | 2000.0 |
| Dorinem 500 | Injection | 500mg/vial | ACI Limited | 2006.02 |
| Perinem 500 | Injection | 500mg/vial | Drug International Ltd. | 2000.0 |