
Dormicum Inj
Form: Injection
Strength: 5mg/5ml
Generic Name: Midazolam
Company: Radiant Pharmaceuticals Ltd.
MRP:৳ 170.0 (Injection)
Is Antibiotic: No
Indications
Dormicum Inj is used for short-term treatment of insomnia and for sedation before surgical or diagnostic procedures.
Pharmacology
Dormicum Inj works through the neurotransmitter gamma-aminobutyric acid (GABA), which helps relax the muscles, sedate the body, and cause sleep, anesthesia, and amnesia. Dormicum Inj enhances GABA’s effect by increasing the frequency of chloride channel openings in the central nervous system, particularly in the heart and muscles.
Dosage & Administration
Oral dosage:
For adults: 7.5-15 mg daily.
For elderly or weak patients: 7.5 mg daily.
For premedication: 15 mg should be taken 30-60 minutes before the procedure.
Intravenous administration:
For endoscopic or cardiovascular procedures in healthy adults: 2.5 mg. For severely ill or elderly patients: 1-1.5 mg.
For induction of anesthesia: 10-15 mg.
Intramuscular administration:
For adults: 0.07-0.1 mg/kg body weight (usually 5 mg).
For children: 0.15-0.20 mg/kg.
For elderly or weak patients: 0.025-0.05 mg/kg.
Rectal administration for children:
0.35-0.45 mg/kg 20-30 minutes before anesthesia.
Interaction
Dormicum Inj can increase the sedative effects of other medications like neuroleptics, tranquilizers, antidepressants, sleep aids, painkillers, anesthetics, antipsychotics, anti-anxiety drugs, anti-epileptic drugs, and sedative antihistamines.
Contraindications
Dormicum Inj should not be used by people with severe breathing problems, severe liver problems, myasthenia gravis, sleep apnea, or a known allergy to benzodiazepines or any of its components.
Side Effects
At the start of treatment, drowsiness, confusion, fatigue, headache, and muscle weakness may occur but usually disappear after a few doses. After IV or IM use, changes in vital signs like breathing problems, low blood pressure, and heart rate changes may occur.
Pregnancy & Lactation
Dormicum Inj should be avoided during pregnancy unless no other options are available. Since Dormicum Inj passes into breast milk, Dormicum Inj should not be used by breastfeeding mothers.
Precautions & Warnings
Dormicum Inj should be given very slowly through IV.
Overdose Effects
Overdosing may cause coma, loss of reflexes, breathing problems, and heart issues. These can be treated with the benzodiazepine antagonist flumazenil.
Therapeutic Class
Dormicum Inj belongs to the class of benzodiazepine hypnotics and sedatives.
Storage Conditions
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.