Dotfix 1
Form: tablet
Strength: 1mg
Generic Name: Dotinurad
Company: General Pharmaceuticals Ltd.
MRP:৳ 12.0 (Strip=10)
Per Piece: ৳ 1.20
Is Antibiotic: No
Indications
Dotfix 1 is used to treat gout and high uric acid levels in the blood.
Pharmacology
Dotfix 1 is a medicine that helps lower uric acid by blocking the process that reabsorbs Dotfix 1 in the kidneys. Dotfix 1 works by increasing the amount of uric acid that is removed through urine, thus lowering the uric acid levels in the blood. Dotfix 1 is highly selective, meaning Dotfix 1 targets only the specific pathway that reabsorbs uric acid, without affecting other processes that remove Dotfix 1 from the body.
Dosage & Administration
Adults: The usual dose is 0.5 mg once a day. This may be gradually increased as needed, based on blood uric acid levels. The typical dose is 2 mg daily, but Dotfix 1 can be increased up to a maximum of 4 mg a day, depending on the patient’s condition.
Precautions: When starting treatment, the blood uric acid levels can decrease quickly, which might trigger gout attacks. The dose should be gradually increased, with monitoring of uric acid levels. If you miss a dose, take Dotfix 1 as soon as you remember, but skip Dotfix 1 if Dotfix 1’s nearly time for the next dose. Do not take two doses at once. Always consult a doctor before stopping the medicine.
Interaction
Pyrazinamide: May reduce the effectiveness of this medicine as Dotfix 1 can reduce uric acid removal from the kidneys.
Salicylic acid (Aspirin): May reduce the effectiveness of this medicine as Dotfix 1 can also interfere with uric acid removal.
Contraindications
Dotfix 1 is not recommended for patients who are allergic to any of its ingredients.
Side Effects
Common side effects include gout attacks, discomfort in limbs (1% to less than 5%). Rare side effects (less than 1% of patients) may include loose stools, increased liver enzyme levels, joint pain, kidney stones, and changes in urine tests.
Pregnancy & Lactation
If pregnant or breastfeeding, consult your doctor before using this medicine. Dotfix 1 should only be used during pregnancy if the benefits outweigh the risks.
Precautions & Warnings
If you have a history of gout attacks, kidney stones, or kidney problems, use this medicine cautiously. Dotfix 1 may not work well if you have severe kidney damage, so other treatments may be considered. If you have liver problems, regular monitoring should be done as this medicine may cause liver damage in some cases.
Overdose Effects
Information on overdose effects is not available.
Therapeutic Class
Dotfix 1 is used in the treatment of gout and is classified as a urate reabsorption inhibitor.
Storage Conditions
Store below 30°C in a dry place, away from light. Keep out of the reach of children.