Microgest 100
Form: Capsule
Strength: 100mg
Generic Name: Progesterone
Company: Renata Limited
MRP:৳ 16.0 (Strip=10)
Per Piece: ৳ 1.60
Is Antibiotic: No
Indications
Microgest 100 is used for the maintenance of pregnancy in cases of threatened or recurrent abortion. Microgest 100 also provides luteal support during fertility treatments like IUI, IVF-ET, and for luteal phase insufficiency. Microgest 100 is used with estrogen in post-menopausal hormone replacement therapy (HRT) and to prevent endometrial hyperplasia when endogenous estrogen is present. Microgest 100 is also used for secondary amenorrhea, dysfunctional uterine bleeding (DUB), premenstrual tension, endometriosis, oocyte donation, and benign mastopathy.
Pharmacology
Microgest 100 contains micronized progesterone, which is the same as the progesterone naturally produced in the body. Micronization helps the body absorb Microgest 100 better. After taking Microgest 100, the progesterone levels in the blood, endometrial, and breast tissue rise significantly. Progesterone binds to serum proteins and is mainly broken down in the liver. The metabolites are then excreted in the bile and urine, with some being recirculated in the body.
Dosage & Administration
Usual Dose: 100 mg to 200 mg, 2 to 3 soft gel capsules daily, either orally or vaginally in divided doses. The dose can vary depending on the condition and the patient’s needs.
Pregnancy Maintenance (Threatened / Recurrent Abortion): 200 to 400 mg per day in divided doses.
In-vitro Fertilization: 200 mg three times a day from embryo transfer until pregnancy is confirmed, continued until the 12th week if pregnant.
HRT: In a sequential regimen: 200 mg daily for 12 days in the last two weeks of the cycle. In a continuous regimen: 100 mg daily with estrogen throughout the month.
Oocyte Donation: 100 mg twice a day from transfer until pregnancy is confirmed, increasing up to 600 mg/day and continuing until the 12th week if pregnant.
Luteal Support: 100 mg three times a day starting from day 17 of the cycle for 10 days, continued until the 12th week if pregnant.
Luteal Phase Insufficiency: 100 mg three times daily, up to 600 mg/day in divided doses if needed, for up to 12 weeks of pregnancy.
Secondary Amenorrhea: 300 mg for 10 days, which works in 80% of cases.
Premenstrual Syndrome: 100 to 200 mg daily for 10 days, from day 17 to day 26 of the cycle.
Benign Mastopathy: 200 to 300 mg for 10 days, usually from day 17 to day 26 of the cycle.
Interaction
Ketoconazole can slow down the breakdown of progesterone in the body.
Contraindications
Microgest 100 should not be used by people who are allergic to any of its ingredients or have liver problems, undiagnosed vaginal bleeding, porphyria, cancers of the uterus, genital organs, or breast, or a history of stroke or blood clots. Microgest 100 is not for use in cases of miscarriage or when there is tissue left in the uterus.
Side Effects
Microgest 100 does not have estrogenic, androgenic, or mineralocorticoid effects. Some mild side effects include drowsiness, depression, breast tenderness, and bloating. These side effects are usually less severe when used vaginally.
Pregnancy cat
N/A
Precautions & Warnings
Microgest 100 should be used carefully in people with kidney problems, diabetes, seizures, migraines, headaches, heart disease, or depression.
Overdose effects
N/A
Therapeutic Class
Drugs for menopausal symptoms, hormone replacement therapy, female sex hormones, oral contraceptive preparations.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Similar Brands of Progesterone (Capsule – 100mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Mygest 100 | Capsule | 100mg | Drug International Ltd. | 15.0 |
| Utrogestan 100 | Capsule | 100mg | ZAS Corporation | 36.0 |
| Utrogest 100 | Capsule | 100mg | Ziska Pharmaceuticals Ltd. | 15.0 |