Mirabeg 25
Form: Tablet
Strength: 25mg
Generic Name: Mirabegron
Company: General Pharmaceuticals Ltd.
MRP:৳ 30.0 (Strip=10)
Per Piece: ৳ 3.00
Is Antibiotic: No
Indications
Mirabeg 25 is used to treat symptoms such as the urgent need to urinate, frequent urination, and incontinence, especially in adults with overactive bladder (OAB) syndrome.
Pharmacology
Mirabeg 25 is the first beta-3 adrenoceptor agonist. Mirabeg 25 works in two ways: directly acting on the bladder muscle and through the nervous system. Mirabeg 25 increases a substance called cyclic AMP, which helps relax the bladder muscle, allowing Mirabeg 25 to hold more urine during the storage phase of the bladder’s fill-void cycle.
Dosage & Administration
Adults & Elderly: Start with one 25 mg tablet daily, with or without food. Based on how well Mirabeg 25’s tolerated, the dose may be increased to one 50 mg tablet daily.
Renal or Hepatic Impairment: Patients with severe kidney or moderate liver issues should not take more than one 25 mg tablet daily. Mirabeg 25 is not recommended for patients with end-stage kidney disease or severe liver problems.
Gender: No adjustment in dose is needed based on gender.
Pediatric Population: The safety and effectiveness of this medicine have not been established for children under 18 years old.
Interaction
Mirabegron may interact with certain enzyme inhibitors, like ketoconazole. No dose adjustment is needed when combined with these inhibitors, but caution is advised in patients with kidney or liver issues.
When taken with certain enzyme inducers like rifampicin, Mirabegron levels may decrease, but no dose adjustment is needed.
Mirabegron can affect the metabolism of some other drugs, so caution is needed when combined with certain medications, especially those metabolized by CYP2D6, like metoprolol, desipramine, and others.
Contraindications
Mirabeg 25 is not recommended for patients who are allergic to any of its ingredients or who have uncontrolled high blood pressure (180/110 mm Hg or higher).
Side Effects
The most common side effects are a fast heart rate (tachycardia) and urinary tract infections. Tachycardia occurred in 1.2% of patients, and urinary tract infections occurred in 2.9%. Serious side effects include atrial fibrillation in 0.2% of patients.
Pregnancy & Lactation
There is limited data on its use in pregnant women, but animal studies have shown potential harm. Mirabeg 25 is not recommended during pregnancy or breastfeeding. Mirabeg 25 is excreted in animal milk, so Mirabeg 25 may also be present in human milk.
Precautions & Warnings
Mirabeg 25 should be used cautiously in patients with kidney or liver problems and high blood pressure. Patients with QT prolongation should be monitored closely. Caution is also advised in patients with bladder issues or those taking other medications for overactive bladder.
Overdose Effects
In case of overdose, symptoms may include a fast heart rate and high blood pressure. Treatment should be supportive, with monitoring of pulse rate, blood pressure, and ECG.
Therapeutic Class
Mirabeg 25 belongs to the class of medicines used to treat urinary retention, incontinence, and benign prostatic hyperplasia (BPH).
Storage Conditions
Store in a cool, dry place, away from light.
Similar Brands of Mirabegron (Tablet – 25mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
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