Omnitrope
Form: Injection
Strength: 5mg/1.5ml
Generic Name: Somatropin
Company: Novartis (Bangladesh) Ltd.
MRP:৳ 9090.29 (Injection)
Is Antibiotic: No
Indications
Omnitrope is used to treat children who have growth problems due to not enough growth hormone. Omnitrope is also used for children with short stature due to Noonan syndrome, Turner syndrome, or being born small for gestational age (SGA) and not showing growth by age 2 to 4 years. For adults, Omnitrope helps replace growth hormone in people with growth hormone deficiency (GHD) caused by pituitary disease, surgery, radiation, or trauma, as well as those who had GHD as children. Omnitrope should be checked for continued use when growth plates are closed in adults who had GHD as children.
Pharmacology
Omnitrope works by attaching to a special receptor on the target cells, triggering a series of effects. Some effects are mainly caused by IGF-I made in the liver, such as skeletal growth and protein production, while others happen directly because of the growth hormone, like fat breakdown.
Dosage & Administration
For Children with Growth Hormone Deficiency: 0.024 to 0.034 mg/kg/day, 6 to 7 times a week.
Noonan Syndrome: Up to 0.066 mg/kg/day.
Turner Syndrome: Up to 0.067 mg/kg/day.
SGA (Born Small for Gestational Age): Up to 0.067 mg/kg/day.
For Adults with Growth Hormone Deficiency: 0.004 mg/kg/day to start, and Omnitrope can be increased to 0.016 mg/kg/day after about 6 weeks. Starting doses can be around 0.2 mg/day (range: 0.15 to 0.30 mg/day), increased every 1 to 2 months by 0.1 to 0.2 mg/day.
Omnitrope should be injected under the skin, and the injection sites should be rotated to prevent tissue damage.
Interaction
If used with glucocorticoids, they may need adjusting. Omnitrope can interact with drugs that are processed by the liver, so those should be monitored. Women may need larger doses when taking oral estrogen. People using insulin or other diabetic medications may need to adjust their doses as well.
Contraindications
Omnitrope should not be used in critically ill patients, children with Prader-Willi syndrome who are obese or have breathing problems, those with active cancer, or people who are allergic to Omnitrope. Omnitrope is also not for children with closed growth plates.
Side Effects
The common side effects include headaches, muscle pain, joint stiffness, high blood sugar, and sugar in the urine.
Pregnancy & Lactation
If pregnant or breastfeeding, talk to your doctor before using Omnitrope. There are no studies on how Omnitrope affects the unborn baby, so Omnitrope should only be used during pregnancy if clearly needed. Omnitrope is not known whether Omnitrope passes into breast milk, so caution is advised when using Omnitrope while nursing.
Precautions & Warnings
Omnitrope should be used carefully in critically ill patients. Children with Prader-Willi syndrome should be checked for breathing issues before starting treatment. People with existing tumors should be monitored for tumor growth. Those with diabetes or glucose problems should have their sugar levels checked regularly, as Omnitrope could worsen these issues. Fluid retention, thyroid problems, and joint issues may develop. People with adrenal or thyroid problems should be closely monitored, and if pain or limping develops, check for potential issues with the hips or bones.
Overdose Effects
Not available.
Therapeutic Class
Drugs for growth failure.
Storage Conditions
Store between 2-8°C. Do not freeze. Keep away from light and out of the reach of children.