Onemox
Form: Capsule
Strength: 500mg
Generic Name: Amoxicillin
Company: Pharmasia Ltd.
MRP:৳ 0.0 (Capsule)
Is Antibiotic: Yes
Indications
Onemox is used to treat infections caused by bacteria that are sensitive to ß-lactamase negative strains. These infections include ear, nose, and throat infections like otitis media, sinusitis, tonsillitis, pharyngitis, and laryngitis. Onemox also treats lower respiratory tract infections such as pneumonia, bronchitis, lung abscess, empyema, and bronchiectasis. Onemox is used for skin and soft tissue infections like cellulitis, carbuncles, and infected wounds. Onemox can treat genito-urinary tract infections such as pyelonephritis, cystitis, and urethritis, as well as venereal diseases like acute uncomplicated gonorrhoea. For dental abscess, Onemox is used for short-term therapy. Additionally, Onemox is used with Clarithromycin and Lansoprazole in triple therapy for treating H. pylori infection and duodenal ulcer disease, and to reduce the risk of duodenal ulcer recurrence.
Pharmacology
Onemox is a broad-spectrum penicillin effective against a wide range of Gram-positive and Gram-negative bacteria. Onemox works by inhibiting the production of the bacterial cell wall. Onemox remains stable in stomach acid and is absorbed quickly after taking Onemox orally. After taking an oral dose, peak blood levels are reached within 1 to 2 hours. Onemox is well-distributed in various body tissues and fluids.
Dosage & Administration
Adults: 250 mg three times a day, increasing to 500 mg three times a day for more severe infections.
Children (up to 10 years old): 125 mg three times a day, increasing to 250 mg three times a day for severe infections. For severe or recurrent respiratory infections, 3 gm every 12 hours is recommended.
Otitis Media: For adults, 1 g three times a day; for children, 40 mg/kg body weight daily in 3 divided doses (max. 3 g daily).
Pneumonia: 500-1000 mg three times a day is recommended.
Dental Abscess: 3 gm, repeated after 10-12 hours.
Urinary Tract Infections: 3 gm, repeated after 10-12 hours.
Gonorrhoea: A single dose of 2-3 gm with 1 gm Probenecid is recommended (Probenecid is not for children under 2 years old).
In Renal Impairment: Dosage may need to be reduced.
Interaction
Taking Onemox with Probenecid may increase and prolong blood levels. Onemox can affect the gut bacteria and reduce the effectiveness of combined oral contraceptives that contain estrogen and progesterone.
Contraindications
Onemox should not be used in patients who are allergic to penicillin.
Side Effects
Side effects are generally mild and temporary. These may include diarrhea, indigestion, or occasionally a rash. Rarely, pseudo-membranous colitis has been reported.
Pregnancy & Lactation
Onemox is classified as pregnancy category B by the FDA. There are no adequate and well-controlled studies in pregnant women, so Onemox should be used during pregnancy only if clearly needed. Onemox is excreted in human milk, so caution is advised when used by lactating mothers.
Precautions & Warnings
Superinfections with fungal or bacterial pathogens may occur during therapy. If this happens, Onemox should be discontinued, and the appropriate treatment should be started.
Overdose Effects
Not applicable.
Therapeutic Class
Broad spectrum penicillins.
Storage Conditions
Store in a dry place, away from light and heat. Keep out of the reach of children.
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