Sergel 20
Form: tablet
Strength: 20mg
Generic Name: Esomeprazole
MRP:৳ 7.0 (Strip=10)
Per Piece: ৳ 0.70
Is Antibiotic: No
Indications
Sergel 20 is used to relieve chronic heartburn symptoms and other symptoms related to GERD. Sergel 20 helps heal erosive esophagitis and maintain its healing. Sergel 20 is also used with amoxicillin and clarithromycin to treat Helicobacter pylori infection in patients with duodenal ulcers. Sergel 20 treats Zollinger-Ellison Syndrome, acid-related dyspepsia, and both duodenal and gastric ulcers.
Pharmacology
Sergel 20 is a proton pump inhibitor that works by blocking gastric acid production in the stomach. Sergel 20 is the S-isomer of omeprazole and provides better acid control than other proton pump inhibitors. Sergel 20 is absorbed in the body and reaches peak levels in about 1.5 hours after taking Sergel 20. The absorption increases with higher doses.
Dosage & Administration
Oral Dosage:
- For healing erosive esophagitis: 20 mg or 40 mg once daily for 4-8 weeks. If healing doesn’t happen, an additional 4-8 weeks of treatment may be needed.
- For maintaining healing: 20 mg once daily (no studies beyond 6 months).
- For symptomatic GERD: 20 mg once daily for 4 weeks. If symptoms continue, another 4 weeks of treatment may be needed.
- For Helicobacter pylori eradication (triple therapy): Esomeprazole 40 mg once daily for 10 days, Amoxicillin 1000 mg twice daily for 10 days, Clarithromycin 500 mg twice daily for 10 days.
- For Zollinger-Ellison Syndrome: 20-80 mg once daily, adjusted individually as needed.
- For acid-related dyspepsia: 20-40 mg once daily for 2-4 weeks depending on the response.
- For duodenal ulcers: 20 mg once daily for 2-4 weeks. For gastric ulcers: 20-40 mg once daily for 4-8 weeks.
IV Injection or Infusion:
- For adult GERD with erosive esophagitis: 20 mg or 40 mg once daily by IV. IV injection lasts >3 minutes, IV infusion lasts 10-30 minutes.
- For pediatric patients (1 to 17 years): Body weight <55 kg: 10 mg once daily. ≥55 kg: 20 mg once daily. For infants (1 month to <1 year): 0.5 mg/kg once daily.
- For preventing rebleeding of gastric or duodenal ulcers: 80 mg by IV infusion for 30 minutes, followed by 8 mg/h for 72 hours.
Interaction
Sergel 20 is mainly broken down in the liver by enzymes. Sergel 20 does not significantly interact with many common drugs. Sergel 20 may reduce the effectiveness of some drugs that need acidic conditions to be absorbed, like ketoconazole, iron salts, and digoxin. Sergel 20 can also affect how other drugs, such as diazepam, are metabolized, potentially increasing their effects.
Contraindications
Sergel 20 should not be used by people who are allergic to any of its ingredients.
Side Effects
Common side effects include headache, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth. These effects are usually mild and temporary.
Pregnancy & Lactation
There are no enough studies on pregnant women, but animal studies have shown no harm. If breastfeeding, talk to your doctor first. Sergel 20 should only be used during pregnancy if clearly needed.
Precautions & Warnings
If you have a history of stomach cancer, esomeprazole may mask the symptoms. Take Sergel 20 with caution if you have liver problems. Also, inform your doctor if you’re taking other medications that could interact.
Overdose Effects
Overdose may cause symptoms like tremors, seizures, and heart issues. There’s no specific antidote, and treatment is supportive. Dialysis is unlikely to help since Sergel 20 is highly protein-bound.
Storage Conditions
Store Sergel 20 in a cool, dry place, away from light and moisture. Keep Sergel 20 out of reach of children.
Similar Brands of Esomeprazole (tablet – 20mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| EMT Mups 20 | tablet | 20mg | Beacon Pharmaceuticals Ltd. | 10.0 |