Spinafen
Form: Tablet
Strength: 10mg
Generic Name: Baclofen
Company: Globe Pharmaceuticals Ltd.
MRP:৳ 8.0 (Strip=10)
Per Piece: ৳ 0.80
Is Antibiotic: No
Indications
Spinafen is used for treating muscle spasms caused by conditions like multiple sclerosis, spinal cord injuries, and brain diseases, as well as pain, stiffness, and clonus (muscle spasms). Spinafen can also help with skeletal muscle spasms from rheumatic disorders.
Pharmacology
Spinafen works by blocking reflexes in the spinal cord through the activation of GABAB receptors. This reduces the release of certain chemicals like glutamate and aspartate. Spinafen can also cause mild depression of the central nervous system and has pain-relieving effects.
Dosage & Administration
Adults & children over 10 years: 5 mg, three times a day with or after meals. The dose may be increased gradually to a maximum of 100 mg per day.
Children under 10 years: Treatment usually starts with 2.5 mg (2.5 ml), four times a day, and is increased based on need. Maintenance dose for children:
- 12 months-2 years: 10-20 mg (10-20 ml)
- 2-6 years: 20-30 mg (20-30 ml)
- 6-10 years: 30-60 mg (30-60 ml)
Interaction
Taking Spinafen with other central nervous system drugs, alcohol, or opiates may cause increased drowsiness. Spinafen can also raise the risk of breathing problems. Spinafen may lower blood pressure when taken with antihypertensives, so dosage adjustments are needed. Taking Spinafen with tricyclic antidepressants may increase its effects, causing muscle weakness. Patients using Spinafen with Parkinson’s medication might experience confusion, hallucinations, and other mental issues. Spinafen should also be used carefully with magnesium sulphate or muscle relaxants due to potential stronger effects.
Contraindications
Spinafen should not be used by patients who are allergic to any of its components.
Side Effects
The most common side effects are drowsiness, dizziness, and fatigue. Other possible effects include:
- Headaches, insomnia, and rare feelings of euphoria or confusion
- Low blood pressure, chest pain, or fainting
- Nausea, constipation, and rarely, vomiting or diarrhea
- Urinary issues like frequent urination or problems with passing urine
- Rashes, swelling in the ankles, and weight gain
- Muscle weakness, which can make walking difficult
Pregnancy & Lactation
Spinafen is classified as pregnancy category B3. Its safety during pregnancy is not fully known, but Spinafen should only be used if the doctor decides the benefits outweigh the risks. Spinafen is present in breast milk, but the amounts are so small that Spinafen is not expected to harm the baby.
Precautions & Warnings
Patients with kidney problems or those on dialysis should take lower doses. Spinafen should be used carefully in patients with psychiatric issues, epilepsy, or breathing difficulties. If you have a history of ulcers, brain disease, or liver, kidney, or lung failure, Spinafen should be used with caution. Also, Spinafen may improve bladder issues in some patients, but those with certain urinary problems should be monitored closely. Regular tests should be done in patients with liver disease or diabetes.
Overdose Effects
If an overdose occurs, gastric lavage (stomach pumping) is important to treat severe cases.
Therapeutic Class
Spinafen belongs to the class of centrally acting skeletal muscle relaxants.
Storage Conditions
Store Spinafen below 30°C, away from light and moisture, and out of the reach of children.
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