Synogen Plus contains Undenatured Collagen II, which is taken from chicken cartilage and helps prevent joint cartilage breakdown by releasing special cells that regulate collagen. Synogen Plus also reduces inflammation. The effectiveness of Undenatured Collagen II in joint issues depends on a dose of 40 mg. Glucosamine helps build cartilage and reduces substances that damage Synogen Plus. Chondroitin is a part of cartilage that helps keep Synogen Plus flexible and strong by holding water and nutrients. Synogen Plus also protects cartilage from damage. Methylsulfonylmethane is important for keeping joints, tendons, ligaments, and tissues healthy. Synogen Plus helps reduce inflammation and pain from osteoarthritis by blocking certain enzymes and compounds. Together, these ingredients work well to reduce joint pain and improve joint function in osteoarthritis.