Tacrolim 0.1%
Form: Ointment
Strength: 0.1%
Generic Name: Tacrolimus 0.1%, 0.03% Topical
Company: Incepta Pharmaceuticals Ltd.
MRP:৳ 200.0 (5gm tube)
Is Antibiotic: No
Indications
Tacrolim 0.1% is used for short-term and long-term treatment of moderate to severe atopic dermatitis in patients who cannot use other therapies due to possible risks or who don’t respond well to them. Tacrolim 0.1% is also used for other skin conditions such as chronic skin issues from a transplant, hand and foot eczema, allergic skin reactions, vitiligo, psoriasis, skin irritation from lichen, vulvar lichen sclerosus, painful skin ulcers from rheumatoid arthritis, steroid-induced rosacea, hair loss, and certain types of rashes.
Pharmacology
Tacrolim 0.1% is an immunomodulator made by a fungus called Streptomyces tsukubaensis. Tacrolim 0.1% works by blocking T-lymphocyte activation, which helps reduce inflammation. The medication binds to a protein inside cells and prevents the activation of certain enzymes that are involved in inflammation.
Dosage & Administration
For adults: Apply a small amount of Tacrolimus ointment to the affected skin areas twice a day, rubbing Tacrolim 0.1% in gently. Continue using for one week after the symptoms of atopic dermatitis clear up. Do not use with occlusive dressings, as the safety of this combination is not known.
For children: Tacrolim 0.1% is safe for children aged 2 years and older to use the 0.03% ointment. The 0.1% ointment can be used for children 16 years and older.
For elderly: There were no significant differences in how the ointment worked for patients over 65 years compared to other adults in studies.
Interaction
There have been no formal studies on how Tacrolimus ointment interacts with other topical drugs. Be careful when using Tacrolim 0.1% with medications that affect liver enzymes, especially in patients with widespread skin conditions. Some examples include erythromycin, ketoconazole, and calcium channel blockers.
Contraindications
Tacrolim 0.1% should not be used by patients who are allergic to Tacrolimus or any ingredient in the ointment.
Side Effects
Side effects from Tacrolimus ointment are rare and mild. These can include burning sensations, itching, flu-like symptoms, allergic reactions, redness of the skin, skin infections, and headaches.
Pregnancy & Lactation
Tacrolim 0.1% is classified as Pregnancy Category C. There are no well-controlled studies on its use during pregnancy. Though the absorption of Tacrolimus through the skin is minimal, Tacrolim 0.1% is known to be excreted in breast milk. You should decide whether to stop breastfeeding or stop using the medication, considering how important the medication is for you.
Precautions & Warnings
Be cautious when using Tacrolimus ointment in patients with atopic dermatitis who are prone to skin infections. Its safety has not been studied in patients with generalized erythroderma (widespread skin redness).
Overdose Effects
Tacrolim 0.1% is not meant for oral use. If swallowed by accident, Tacrolim 0.1% may cause side effects similar to those seen with systemic Tacrolimus. Seek medical advice immediately if this happens.
Therapeutic Class
Tacrolim 0.1% is classified as a drug that affects the immune response.
Storage Conditions
Store Tacrolim 0.1% below 30°C, away from light, and keep out of reach of children.
Similar Brands of Tacrolimus 0.1%, 0.03% Topical (Ointment – 0.1%)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Prolimus | Ointment | 0.1% | Healthcare Pharmaceuticals Ltd. | 1000.0 |
| Remus 0.1% 10gm | Ointment | 0.1% | Square Pharmaceuticals Ltd. | 360.0 |
| Remus 0.1% 30gm | Ointment | 0.1% | Square Pharmaceuticals Ltd. | 1000.0 |
| Rolimus 0.1% | Ointment | 0.1% | Opsonin Pharma Limited | 360.0 |
| Vitilimus | Ointment | 0.1% | Unimed Unihealth Pharmaceuticals Ltd. | 1000.0 |