Taf 25
Form: Tablet
Strength: 25mg
Generic Name: Tenofovir Alafenamide
Company: Beacon Pharmaceuticals Ltd.
MRP:৳ 160.0 (Strip=10)
Per Piece: ৳ 16.00
Is Antibiotic: No
Indications
Taf 25 is used for treating chronic hepatitis B virus (HBV) infection in adults with stable liver disease.
Pharmacology
Taf 25 is a prodrug of tenofovir, which enters liver cells and is converted into the active form. The active form, tenofovir diphosphate, stops HBV from replicating by preventing the virus from copying its DNA. Taf 25 does not cause damage to mitochondria in cells.
Dosage & Administration
Prior to Starting Treatment: Patients should be tested for HIV-1 infection before starting Taf 25. Taf 25 should not be used alone in patients with HIV-1 infection.
Adult Dosage: The recommended dosage is one 25 mg tablet once a day with food.
Renal Impairment: No dosage change is needed for patients with mild kidney issues or those on dialysis. If on dialysis, take Taf 25 after dialysis.
Liver Impairment: No dosage change is needed for mild liver problems, but Taf 25 is not recommended for patients with severe liver issues.
Pediatric Use: Taf 25 is not recommended for children under 18.
Geriatric Use: No significant difference in safety or effectiveness has been observed in elderly patients.
Interaction
Taf 25 is affected by drugs that change the activity of P-glycoprotein (P-gp) and BCRP, which could either reduce or increase its absorption. Taf 25 should not be taken with drugs that reduce kidney function or compete for kidney processing, as this may increase side effects.
Contraindications
Taf 25 is not recommended for patients with HIV-1 infection when used alone.
Side Effects
Common side effects include headache, stomach pain, tiredness, cough, nausea, and back pain. Serious side effects include liver issues, kidney problems, and a buildup of lactic acid in the blood.
Pregnancy & Lactation
If pregnant, consult a doctor before taking Taf 25. There is a slight risk of birth defects when used during pregnancy. Taf 25 is not known if Taf 25 passes into breast milk, so consult a doctor if breastfeeding.
Precautions & Warnings
Discontinuing Taf 25 may lead to a worsening of hepatitis B. Taf 25 should be used cautiously in patients with kidney problems and those taking other drugs that can affect the kidneys.
Overdose Effects
In case of overdose, supportive care is needed. Taf 25 can be removed from the body through hemodialysis.
Therapeutic Class
Hepatitis B treatment.
Storage Conditions
Store below 30°C, in its original container, away from light, and out of the reach of children.
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