Tapazol 5
Form: tablet
Strength: 5mg
Generic Name: Methimazole
MRP:৳ 6.0 (Strip=30)
Per Piece: ৳ 0.20
Is Antibiotic: No
Indications
Tapazol 5 is used to treat patients with Graves’ disease with hyperthyroidism or toxic multinodular goiter when surgery or radioactive iodine therapy is not suitable. Tapazol 5 is also used to reduce symptoms of hyperthyroidism before thyroid surgery or radioactive iodine therapy.
Pharmacology
Tapazol 5 works by blocking the production of thyroid hormones, making Tapazol 5 effective in treating hyperthyroidism. Tapazol 5 does not affect thyroid hormones already present in the body. Tapazol 5 is absorbed in the gastrointestinal tract, processed in the liver, and removed through the urine.
Dosage & Administration
Adults: The usual starting dose is 15 mg for mild hyperthyroidism, 30 to 40 mg for moderate cases, and 60 mg for severe cases, taken in 3 doses throughout the day. The maintenance dose is 5 to 15 mg daily.
Pediatric patients: The initial dose is 0.4 mg per kg of body weight, divided into 3 doses. The maintenance dose is about half of the starting dose.
For children and adolescents: Due to potential liver problems with another medication, Methimazole is preferred for treating hyperthyroidism in children.
Interaction
With medicine: Tapazol 5 may increase the effects of blood thinners like warfarin. Tapazol 5 may also affect the use of beta-blockers, digitalis, and theophylline. Adjustments in dosages may be necessary.
With food: Tapazol 5 should be taken consistently in relation to meals as food can change how well Tapazol 5 is absorbed.
Contraindications
Tapazol 5 should not be used by anyone who is allergic to the drug or any of its components.
Side Effects
Common: Skin rash, hives, nausea, vomiting, stomach pain, joint pain, tingling, loss of taste, hair loss, muscle pain, headache, itching, drowsiness, nerve pain, swelling, dizziness, skin color changes, yellowing of the skin, and swelling of salivary glands.
Rare: Serious side effects like low white blood cell count, low platelets, anemia, drug fever, lupus-like symptoms, liver damage, inflammation of blood vessels, and low blood clotting factors.
Pregnancy & Lactation
Tapazol 5 is classified as Pregnancy Category D. Tapazol 5 may cause birth defects if used during the first trimester of pregnancy. If you are pregnant or breastfeeding, talk to your doctor before using this medication. While Tapazol 5 passes into breast milk, Tapazol 5 usually does not affect nursing babies if thyroid function is monitored regularly.
Precautions & Warnings
Birth defects: Tapazol 5 can cause harm to a fetus, especially in the first trimester, so use the lowest effective dose during pregnancy.
Agranulocytosis: A dangerous reduction in white blood cells that can lead to infection. Report any symptoms like fever or sore throat immediately.
Liver damage: If you notice signs of liver problems, like jaundice, stop the medication immediately.
Thyroid function: Tapazol 5 can cause hypothyroidism, so regular thyroid tests are necessary. If hypothyroidism develops, the dose may need to be adjusted.
Overdose Effects
Overdose symptoms may include nausea, vomiting, stomach pain, headache, fever, joint pain, itching, and swelling. In severe cases, Tapazol 5 can cause blood cell issues, liver problems, or kidney damage. Seek immediate medical help in case of overdose.
Therapeutic Class
Tapazol 5 is an anti-thyroid medication.
Storage Conditions
Store in a cool, dry place below 30°C, away from light and out of reach of children.
Similar Brands of Methimazole (tablet – 5mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Thyzol 5 | tablet | 5mg | Ziska Pharmaceuticals Ltd. | 6.0 |