Othera 20
Form: Tablet
Strength: 20mg
Generic Name: Esomeprazole Magnesium Trihydrate
Company: ACI Limited
MRP:৳ 11.0 (Strip=10)
Per Piece: ৳ 1.10
Is Antibiotic: No
Indications
Othera 20 is used to treat conditions such as gastro-esophageal reflux disease (GERD), reduce the risk of gastric ulcers caused by NSAIDs, help eliminate H. pylori infection (as part of triple therapy), and manage Zollinger-Ellison syndrome and excessive stomach acid production.
Pharmacology
Othera 20 works by blocking a specific enzyme in the stomach, which reduces stomach acid production. This helps in healing ulcers and treating acid reflux. Othera 20 is also used to prevent ulcers caused by NSAIDs.
Dosage & Administration
For erosive esophagitis: Adults and children (12-18 years): 40 mg once daily for 4 weeks.
For maintenance of healing of erosive esophagitis: Adults and children (12-18 years): 20 mg once daily.
For risk reduction in NSAID-associated gastric ulcer: Adults: 20 mg once daily for 4-8 weeks.
For H. pylori eradication: Adults and children (12-18 years): 20 mg twice daily for 7 days, in combination with 1000 mg Amoxicillin and 500 mg Clarithromycin.
For Zollinger-Ellison syndrome: Adults: 40-80 mg twice daily.
For children (1-11 years): Erosive esophagitis: 10 mg once daily for 8 weeks (for children weighing less than 20 kg) and 10 mg or 20 mg once daily for 8 weeks (for children weighing 20 kg or more). Maintenance of healing of erosive esophagitis: 10 mg once daily.
For children under 1 year: Othera 20 is not recommended for children younger than 1 year.
Interaction
Othera 20 is broken down by the liver enzymes CYP2C19 and CYP3A4. Othera 20 does not significantly interact with drugs metabolized by most other enzymes. However, Othera 20 may affect the absorption of some medications like ketoconazole, iron, and digoxin. Othera 20 can also interact with diazepam, increasing its levels in the blood.
Contraindications
Othera 20 should not be used by individuals who are allergic to any of its components.
Side Effects
The most common side effects include headaches, nausea, diarrhea, flatulence, abdominal pain, constipation, and dry mouth. These side effects are usually mild and temporary.
Pregnancy & Lactation
Othera 20 is recommended to use caution during pregnancy. Othera 20 is not known if Othera 20 passes into breast milk, so consult a doctor before using Othera 20 while breastfeeding.
Precautions & Warnings
Othera 20 should be used carefully in patients with severe liver or kidney issues. Long-term use may slightly increase the risk of bone fractures, especially in the hip, wrist, or spine.
Overdose Effects
Details about overdose effects are not provided.
Therapeutic Class
Othera 20 belongs to the class of proton pump inhibitors.
Storage Conditions
Store Othera 20 in a cool, dry place below 25ºC, away from light. Keep out of reach of children.
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