Xelnib XR 11
Form: Tablet
Strength: 11mg
Generic Name: Tofacitinib
Company: Opsonin Pharma Limited
MRP:৳ 80.0 (Box=10)
Per Piece: ৳ 8.00
Is Antibiotic: No
Indications
Xelnib XR 11 is used to treat rheumatoid arthritis in adults who have not responded well or are unable to tolerate methotrexate. Xelnib XR 11 can be taken alone or with methotrexate or other similar medicines.
Xelnib XR 11 is also used for adults with active psoriatic arthritis who have not responded well or are unable to tolerate methotrexate or other similar medicines.
Xelnib XR 11 is used to treat adults with moderate to severe ulcerative colitis.
Pharmacology
Rheumatoid arthritis is an autoimmune disease that causes inflammation and joint damage due to abnormal immune cell activity. Tofacitinib works by blocking the signals from certain proteins in the body that cause inflammation and immune cell activation. This helps reduce inflammation and damage to the joints.
Xelnib XR 11 works by inhibiting the JAK-STAT pathway, which is important in immune cell function and the production of red blood cells. Tofacitinib may also have other ways of reducing inflammation.
Dosage & Administration
Rheumatoid Arthritis: Take 5 mg twice a day or 11 mg once a day. For those with moderate kidney or liver problems, take 5 mg once a day.
Psoriatic Arthritis: Take 5 mg twice a day or 11 mg once a day, in combination with other medications. For those with moderate kidney or liver problems, take 5 mg once a day.
Ulcerative Colitis: Take 10 mg twice a day for at least 8 weeks, then reduce to 5 or 10 mg twice a day. If no improvement is seen after 16 weeks, stop the treatment. Use the lowest effective dose to maintain the response.
Interaction
Do not take with strong inhibitors of Cytochrome P450 3A4 (e.g., Ketoconazole). If using medications that moderately affect CYP3A4 and strongly affect CYP2C19 (e.g., fluconazole), take 5 mg once a day.
Taking medications that strongly induce CYP enzymes (e.g., Rifampin) may reduce the effectiveness of this medication.
Contraindications
Xelnib XR 11 is not recommended for use in certain patients with serious infections or other health conditions, but no specific contraindications have been listed.
Side Effects
Common side effects during the first three months of treatment include upper respiratory infections, headaches, diarrhea, and nasal congestion.
Pregnancy & Lactation
If you are pregnant, planning to become pregnant, or breastfeeding, contact your doctor before using this medication. Xelnib XR 11 should only be used during pregnancy if the potential benefits outweigh the risks to the baby.
Xelnib XR 11 is not known if this medication is passed into breast milk, so a decision should be made whether to stop breastfeeding or stop the medication, considering the benefits of the medication to the mother.
Precautions & Warnings
Be cautious when using this medication in patients who may develop iron overload or have serious infections. Do not take live vaccines while using this medication. Regular blood tests are recommended to monitor for any changes in blood cell counts, liver function, and other health markers.
Do not start treatment if your lymphocyte count is too low, or if your neutrophil count or hemoglobin levels are too low.
Overdose Effects
There are no specific details available about overdose effects for this medication.
Therapeutic Class
Xelnib XR 11 is classified as an immunosuppressant.
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of the reach of children.
Similar Brands of Tofacitinib (Tablet – 11mg)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Arthanib XR | Tablet | 11mg | Aristopharma Limited | 80.0 |
| Jaktor XR | Tablet | 11mg | Beacon Pharmaceuticals Ltd. | 75.0 |
| Tocit XR | Tablet | 11mg | Drug International Ltd. | 75.0 |
| Tofacent XR | Tablet | 11mg | Incepta Pharmaceuticals Ltd. | 80.0 |
| Tofacinix | Tablet | 11mg | Beacon Pharmaceuticals Ltd. | 75.0 |
| Tofacit XR 11 | Tablet | 11mg | Delta Pharma Limited | 60.0 |
| Tofanib XR 11 | Tablet | 11mg | Globe Pharmaceuticals Ltd. | 80.0 |
| Tofatin XR | Tablet | 11mg | Ziska Pharmaceuticals Ltd. | 80.0 |