Xelpro
Form: Capsule
Strength: 20mg
Generic Name: Esomeprazole Magnesium Trihydrate
Company: Pharmasia Ltd.
MRP:৳ 8.0 (Strip=10)
Per Piece: ৳ 0.80
Is Antibiotic: No
Indications
Xelpro is used to treat conditions such as gastro-esophageal reflux disease (GERD), reduce the risk of gastric ulcers caused by NSAIDs, help eliminate H. pylori infection (as part of triple therapy), and manage Zollinger-Ellison syndrome and excessive stomach acid production.
Pharmacology
Xelpro works by blocking a specific enzyme in the stomach, which reduces stomach acid production. This helps in healing ulcers and treating acid reflux. Xelpro is also used to prevent ulcers caused by NSAIDs.
Dosage & Administration
For erosive esophagitis: Adults and children (12-18 years): 40 mg once daily for 4 weeks.
For maintenance of healing of erosive esophagitis: Adults and children (12-18 years): 20 mg once daily.
For risk reduction in NSAID-associated gastric ulcer: Adults: 20 mg once daily for 4-8 weeks.
For H. pylori eradication: Adults and children (12-18 years): 20 mg twice daily for 7 days, in combination with 1000 mg Amoxicillin and 500 mg Clarithromycin.
For Zollinger-Ellison syndrome: Adults: 40-80 mg twice daily.
For children (1-11 years): Erosive esophagitis: 10 mg once daily for 8 weeks (for children weighing less than 20 kg) and 10 mg or 20 mg once daily for 8 weeks (for children weighing 20 kg or more). Maintenance of healing of erosive esophagitis: 10 mg once daily.
For children under 1 year: Xelpro is not recommended for children younger than 1 year.
Interaction
Xelpro is broken down by the liver enzymes CYP2C19 and CYP3A4. Xelpro does not significantly interact with drugs metabolized by most other enzymes. However, Xelpro may affect the absorption of some medications like ketoconazole, iron, and digoxin. Xelpro can also interact with diazepam, increasing its levels in the blood.
Contraindications
Xelpro should not be used by individuals who are allergic to any of its components.
Side Effects
The most common side effects include headaches, nausea, diarrhea, flatulence, abdominal pain, constipation, and dry mouth. These side effects are usually mild and temporary.
Pregnancy & Lactation
Xelpro is recommended to use caution during pregnancy. Xelpro is not known if Xelpro passes into breast milk, so consult a doctor before using Xelpro while breastfeeding.
Precautions & Warnings
Xelpro should be used carefully in patients with severe liver or kidney issues. Long-term use may slightly increase the risk of bone fractures, especially in the hip, wrist, or spine.
Overdose Effects
Details about overdose effects are not provided.
Therapeutic Class
Xelpro belongs to the class of proton pump inhibitors.
Storage Conditions
Store Xelpro in a cool, dry place below 25ºC, away from light. Keep out of reach of children.
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