Xofyl 400
Form: Tablet
Strength: 400mg
Generic Name: Doxofylline
Company: The Ibn Sina Pharmaceutical Ind. Ltd.
MRP:৳ 8.0 (Strip=10)
Per Piece: ৳ 0.80
Is Antibiotic: No
Indications
Xofyl 400 is used to treat conditions like bronchial asthma, bronchospasm, chronic obstructive pulmonary disease (COPD), and pulmonary disease with spastic bronchial component.
Pharmacology
Xofyl 400 is a new bronchodilator. Unlike Theophylline, Xofyl 400 has a dioxolane group in its structure. Xofyl 400 works by relaxing bronchial muscles and has a better safety profile. Xofyl 400 also inhibits platelet activation and reduces leukotriene production.
Dosage & Administration
Elderly: 200 mg tablet two or three times daily.
Adults: 400 mg tablet two or three times daily or as directed by the physician.
Children:
>12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.
6-12 years of age: 6-9 mg/kg body weight two times daily. For example, if the body weight is 10 kg, 3 ml (60 mg) two times daily.
If the required daily dose is 400 mg, Doxophylline SR tablet should be taken once daily or as prescribed by the physician.
Interaction
Xofyl 400 should not be taken with other xanthine medications. Limit caffeine intake from food and drinks. Caution is needed when used with ephedrine or other similar drugs. Some drugs, like erythromycin, allopurinol, and others, may increase the drug’s effect, while smoking and other drugs like phenytoin may reduce Xofyl 400. Dosage adjustments may be needed.
Contraindications
Xofyl 400 is not recommended for people who are allergic to the drug or other xanthine derivatives. Xofyl 400 is also not recommended for people with acute heart attacks, low blood pressure, or for breastfeeding mothers.
Side Effects
Some side effects may include nausea, vomiting, stomach pain, headache, irritability, trouble sleeping, fast heartbeat, and trouble breathing. In rare cases, Xofyl 400 could cause high blood sugar or albumin in the urine. If overdosed, severe heart problems or seizures can occur. If side effects happen, the treatment may be stopped, but can be restarted at a lower dose after symptoms improve.
Pregnancy & Lactation
Animal tests have shown that Xofyl 400 does not affect the growth of babies before or after birth. However, there is not enough information about its safety during pregnancy, so Xofyl 400 should be used carefully. Xofyl 400 is not recommended for breastfeeding mothers.
Precautions & Warnings
People with liver disease, heart disease, lung disease, and other conditions should use Xofyl 400 carefully. Xofyl 400 should be monitored in patients with conditions like congestive heart failure as the drug stays in the body longer. Xofyl 400 is not addictive and does not cause dependence.
Overdose Effects
If an overdose occurs, severe heart problems or seizures may happen. There is no specific antidote, so treatment should focus on relieving symptoms. The drug may be restarted at a lower dose once symptoms of overdose are gone.
Therapeutic Class
Xofyl 400 is a bronchodilator and a methyl xanthine derivative.
Storage Conditions
Store in a dry place, away from light and heat. Keep out of children’s reach. Use only with a prescription from a specialist doctor.
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