Xovir
Form: Injection
Strength: 1gm/vial
Generic Name: Acyclovir
Company: Beacon Pharmaceuticals Ltd.
MRP:৳ 1203.61 (1gm Vial)
Is Antibiotic: No
Indications
Xovir is used to treat severe Herpes simplex in people with weak immune systems, serious genital herpes, chickenpox in weak immune patients, and shingles in those with severe symptoms. Xovir also treats Herpes simplex infection in the brain.
Pharmacology
Xovir works by stopping the virus from multiplying. Inside infected cells, Xovir changes into its active form, which blocks the virus from making more DNA, preventing its spread.
Dosage & Administration
For Herpes simplex: 5 mg/kg every 8 hours.
For severe shingles: 5 mg/kg every 8 hours.
For chickenpox in weak immune patients: 10 mg/kg every 8 hours.
For brain infection from Herpes simplex: 10 mg/kg every 8 hours.
Each dose should be given as a slow IV infusion over one hour.
Interaction
Taking Xovir with probenecid slows its removal from the body, increasing its effects. In older adults, using Xovir with diuretics can raise its levels significantly.
Contraindications
Xovir should not be used by people allergic to Xovir or to Valacyclovir.
Side Effects
Some side effects include drowsiness, confusion, tremors, hallucinations, nausea, vomiting, skin rash, and increased liver enzymes. If injected incorrectly, Xovir can cause swelling and irritation at the site.
Pregnancy & Lactation
Xovir should only be used in pregnancy if the benefits outweigh the risks. If breastfeeding, Xovir should only be taken if necessary.
Precautions & Warnings
Xovir must be given slowly through IV and never by mouth. Patients should drink plenty of water to prevent kidney problems. Those with kidney disease, dehydration, or using other kidney-harming drugs should be cautious.
Overdose Effects
Overdose can cause kidney failure, confusion, hallucinations, agitation, seizures, and coma. Drinking water helps prevent crystal buildup in urine. Dialysis may be needed to remove excess drug.
Therapeutic Class
Treatment for Herpes simplex and Varicella-zoster infections.
Storage Conditions
Store between 15°C and 25°C, away from light and moisture. Keep out of children’s reach.