Zentixol A
Form: Injection
Strength: 50mg/ml
Generic Name: Zuclopenthixol
Company: Incepta Pharmaceuticals Ltd.
MRP:৳ 400.0 (Injection)
Is Antibiotic: No
Indications
Zentixol A is used to manage the symptoms of schizophrenia. Zentixol A helps in the initial treatment of acute psychotic episodes or when psychosis related to schizophrenia worsens.
Pharmacology
Zentixol A is a thioxanthene derivative that strongly binds to dopamine D1 and D2 receptors. Zentixol A also binds to α1-adrenergic and 5-HT2 receptors. Zentixol A has weaker activity against histamine H1 and very little effect on muscarinic cholinergic and α2-adrenergic receptors.
Dosage & Administration
Zuclopenthixol Tablets: Start with a dose of 10-50 mg per day, divided into 2 or 3 doses. Zentixol A can be increased by 10-20 mg every 2-3 days based on the patient’s response. The usual dose is 20-60 mg per day, but Zentixol A may vary. Dosages above 100 mg per day are not recommended. For maintenance, the dose is generally reduced to the lowest level that controls symptoms, usually 20-40 mg per day.
Zuclopenthixol Acuphase: The typical dose is 50-150 mg (1-3 ml), injected intramuscularly. The dose can be repeated every 2-3 days if needed. Some patients may need an extra injection 1 or 2 days after the first.
Zuclopenthixol Depot: The usual dose for maintenance therapy is 150-300 mg intramuscularly every 2-4 weeks. Some patients may need a higher or lower dose, or a different schedule.
Interaction
Zentixol A may interact with the following drugs:
- Tricyclic antidepressants
- Guanethidine and similar blood pressure-lowering medicines
- Barbiturates and related drugs
- Levodopa and Parkinson’s medications
- Metoclopramide (used for gastrointestinal issues)
- Other antipsychotic drugs (e.g., thioridazine)
- Medicines that affect heart rhythm (e.g., quinidine, amiodarone, sotalol, erythromycin, moxifloxacin, lithium)
Contraindications
Zentixol A is not recommended for individuals who are intoxicated by alcohol, barbiturates, or opiates, or those with CNS depression, coma, subcortical brain damage, or circulatory collapse. Zentixol A should not be used by patients allergic to thioxanthenes or any ingredient in the formulation.
Side Effects
Common side effects include racing heart, palpitations, tremors, muscle stiffness, abnormal movements, and muscle contractions (dystonia).
Pregnancy & Lactation
The safety of using Zentixol A during pregnancy has not been confirmed. Zentixol A is passed into breast milk, and its safety during breastfeeding has not been established. Consult your doctor before use if you are pregnant, planning to become pregnant, or breastfeeding.
Precautions & Warnings
Take caution if you have ever used treatments for schizophrenia and had problems with them. Also, take caution if you are on other medications, are pregnant or breastfeeding, drink alcohol, or have certain conditions like liver problems, Parkinson’s disease, a history of seizures, dementia, glaucoma, kidney problems, a history of strokes, or a history of blood clots. Special care is needed if you are being treated for cancer (for Zuclopenthixol Depot), or using other antipsychotic drugs.
Overdose Effects
Overdose symptoms may include drowsiness, coma, abnormal movements, convulsions, shock, and changes in body temperature.
Therapeutic Class
Zentixol A belongs to the class of Phenothiazine related drugs.
Storage Conditions
Store Zentixol A between 15°C and 25°C, away from light.