Zinacef
Form: Injection
Strength: 750mg/5ml
Generic Name: Cefuroxime
Company: GlaxoSmithKline
MRP:৳ 0.0 (Injection)
Is Antibiotic: Yes
Indications
Zinacef is used to treat infections caused by bacteria that are sensitive to Zinacef. This includes conditions like:
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
- Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes.
Pharmacology
Zinacef contains Cefuroxime, a second-generation antibiotic that kills bacteria by preventing them from making their cell walls. Zinacef works against a wide range of Gram-positive and Gram-negative bacteria, including those that produce beta-lactamase.
Zinacef also contains Clavulanic acid, which blocks beta-lactamase enzymes. This helps protect Cefuroxime from being broken down, making Zinacef more effective in treating infections caused by bacteria resistant to some antibiotics.
Dosage & Administration
Adolescents and adults (13 years and older):
- Pharyngitis/tonsillitis: 250 mg twice a day for 5-10 days
- Acute bacterial maxillary sinusitis: 250 mg twice a day for 10 days
- Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice a day for 10 days
- Secondary bacterial infections of acute bronchitis: 250-500 mg twice a day for 5-10 days
- Uncomplicated skin infections: 250-500 mg twice a day for 10 days
- Uncomplicated urinary tract infections: 250 mg twice a day for 7-10 days
- Uncomplicated Gonorrhoea: 1000 mg twice a day, single dose
- Community acquired pneumonia: 250-500 mg twice a day for 5-10 days
- MDR Typhoid Fever: 500 mg twice a day for 10-14 days
- Early Lyme disease: 500 mg twice a day for 20 days
Pediatric patients (3 months to 12 years):
- Pharyngitis/Tonsillitis: 20 mg/kg/day twice a day for 5-10 days
- Acute otitis media: 30 mg/kg/day twice a day for 10 days
- Acute bacterial maxillary sinusitis: 30 mg/kg/day twice a day for 10 days
- Impetigo: 30 mg/kg/day twice a day for 10 days
Zinacef can be taken with or without food.
Interaction
If taken with probenecid, Zinacef increases the amount of the medicine in your body. Medicines that reduce stomach acidity may make Zinacef less effective by reducing its absorption.
Contraindications
Zinacef should not be taken by people who are allergic to cephalosporins or have Pseudomembranous Colitis.
Side Effects
Generally, Zinacef is well tolerated. Some common side effects may include nausea, vomiting, diarrhea, and stomach pain. Prolonged use may cause the growth of resistant microorganisms. In rare cases (<0.2%), Zinacef may cause kidney problems, severe allergic reactions, swelling, rashes, or other serious effects.
Pregnancy & Lactation
Zinacef should be avoided during the first trimester if possible. However, Zinacef can be safely used during later stages of pregnancy to treat infections. Zinacef can pass into breast milk in small amounts, so caution is needed when nursing.
Precautions & Warnings
Zinacef should be used carefully in patients who are taking strong diuretics or have a history of colitis.
Overdose Effects
No information available.
Therapeutic Class
Second-generation Cephalosporins, Vaccines, Anti-sera & Immunoglobulins.
Storage Conditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of reach of children.
Similar Brands of Cefuroxime (Injection – 750mg/5ml)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Rofurox IM / IV | Injection | 750mg/5ml | Radiant Pharmaceuticals Ltd. | 250.0 |
| Staxim IV/IM | Injection | 750mg/5ml | Delta Pharma Limited | 125.0 |